DEVELOPMENT OF LIPID NANOSTRUCTURES CONTAINING A PARIETARIA POLLEN ALLERGEN.

L'allergene maggiore di Parietaria judaica Parj 1.0101 contiene una regione capace di legare LPS e con attività immunomodulatoria

Attività immunomodulatoria del peptide PAR37 derivato dall'allergene maggiore di Parietaria judaica ParJ1.0101

Study on Posidonia oceanica (L.) Delile roots growing on different substrata by isto-anatomical and micro-morphological analysis

Posidonia oceanica (L.) Delile grows on different substratum types, ranging from sand, which is easily penetrable by the roots, to rock, in which they are able to enter through crevices (1). In this study a survey was carried out on roots of plagiotropic rhizomes growing on sand (matte), and rock (dolonstone and calcarenite), to assess difference in morphological and anatomical features. In particular, for each substratum, nine rhizomes were randomly sampled by scuba diver at 10 meters of depth. In each rhizome histological and morphometric data (2, 3) were recorded on roots up to the second lateral order. Roots on rock were isolated from their substratum by chemical dissolution. Data analy…

Fine characterization of immunological mechanisms mediated by the major allergens of Parietaria judaica and by a hypoallergenic hybrid, rPjEDcys.

Allergy is a hypersensitivity disease IgE-mediated, affecting more than 25% of the population. Actually the only curative treatment of allergies is Allergen-Specific Immunotherapy (SIT). Recombinant hypoallergenic allergen derivatives with reduced allergenic activity have been engineered to reduce side effects during SIT. Parietaria judaica (Pj) pollen contains two major allergens, Par j 1 and expressing disulphide bond variants of Par j 1 and Par j 2, was generated. The aim of this research project is to compare the immunological mechanisms activated by the major allergens of Pj and by rPjEDcys. In vitro analysis suggested that rPjEDcys has a reduced allergenity and maintains T cells react…