Access to α-Aminophosphonic Acid Derivatives and Phosphonopeptides by [Rh(P–OP)]-Catalyzed Stereoselective Hydrogenation
The hydrogenation of N-substituted vinylphosphonates using rhodium complexes derived from P–OP ligands L1, ent-L1, or (R,R)-Me-DuPHOS as catalysts has been successfully accomplished, achieving very high levels of stereoselectivity (up to 99% ee or de). The described synthetic strategy allowed for the efficient preparation of α-aminophosphonic acid derivatives and phosphonopeptides, which are valuable building blocks for the preparation of biologically relevant molecules.
CCDC 1996308: Experimental Crystal Structure Determination
Related Article: Héctor Fernández-Pérez, Pawel Lenartowicz, Lucas Carreras, Arnald Grabulosa, Pawel Kafarski, Anton Vidal-Ferran|2020|J.Org.Chem.|85|14779|doi:10.1021/acs.joc.0c00914