Release and permeation profiles of spray-dried chitosan microparticles containing caffeic acid

Made available in DSpace on 2018-12-11T17:17:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01 Caffeic acid (CA), a phenolic compound found in plants with antioxidant and antimicrobial activity, induces collagen production and prevents premature aging of the skin. The objective of this study was to develop two types of chitosan microparticles (MP) containing CA and to relate the morphology with the release and permeation profiles. One type of MP was prepared from a hydroalcoholic solution (MPI) and the other from an aqueous solution (MPII). Their morphology and size was evaluated by high-resolution scanning electron microscopy. The release profile of CA was evaluated using the…