Histone Deacetylase Inhibitors

Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. Some of these compounds possess HDACi properties.

CYTOTOXIC POTENTIAL OF AQUEOUS EXTRACTS FROM RHIZOMES AND LEAVES OF POSIDONIA OCEANICA (L.) DELILE AGAINST HEPG2 CANCER CELLS

REPORT OF MEETING Report of the VIIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (IADCI) 10 and 11 February 2005, Consorzio Universitario Provincia di Trapani, Trapani