0000000000877102
AUTHOR
Benedetti M
The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility
Abstract:We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects and 68,284 control subjects and establish a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 independent associations within the extended MHC. We used an ensemble of methods to prioritize up to 551 potentially associated MS susceptibility genes, that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we do find enrichment for MS genes in these brain -…
Les adjectifs verbaux d’obligation (AVO) en védique, grec ancien et latin, d’un point de vue systématique
The volume contains the proceedings of the conference about »Verbal adjectives and participles in Indo-European languages«, which took place in Paris, in September 2014, as a thematic symposium (»Arbeitstagung«) of the Society for Indo-European Studies (Indogermanische Gesellschaft/Société des Études Indo-Européennes). The aim of the conference was to highlight convergences and divergences in the treatment of verbal adjectives and participles across the Indo-European languages, modern as well as ancient.