0000000000879685
AUTHOR
Qi Wang
Identification of susceptibility genes in non-syndromic cleft lip with or without cleft palate using whole-exome sequencing
Background Non-syndromic cleft lip with or without cleft palate (NSCL/P) is among the most common congenital malformations. The etiology of NSCL/P remains poorly characterized owing to its complex genetic heterogeneity. The objective of this study was to identify genetic variants that increase susceptibility to NSCL/P. Material and Methods Whole-exome sequencing (WES) was performed in 8 fetuses with NSCL/P in China. Bioinformatics analysis was performed using commercially available software. Variants detected by WES were validated by Sanger sequencing. Results By filtering out synonymous variants in exons, we identified average 8575 nonsynonymous single nucleotide variants (SNVs). We subseq…
Scalable Virtual Network Video-Optimizer for Adaptive Real-Time Video Transmission in 5G Networks
The increasing popularity of video applications and ever-growing high-quality video transmissions (e.g., 4K resolutions), has encouraged other sectors to explore the growth of opportunities. In the case of health sector, mobile Health services are becoming increasingly relevant in real-time emergency video communication scenarios where a remote medical experts’ support is paramount to a successful and early disease diagnosis. To minimize the negative effects that could affect critical services in a heavily loaded network, it is essential for 5G video providers to deploy highly scalable and priorizable in-network video optimization schemes to meet the expectations of a large quantity of vide…
Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice
Abstract In hippocampus, two guanylyl cyclases (NO-GC1 and NO-GC2) are involved in the transduction of the effects of nitric oxide (NO) on synaptic transmission. However, the respective roles of the NO-GC isoforms on synaptic transmission are less clear in other regions of the brain. In the present study, we used knock-out mice deficient for the NO-GC1 isoform (NO-GC1 KO) to analyze its role in the glutamatergic and GABAergic neurotransmission at pyramidal neurons in layers II/III of somatosensory cortex. NO-GC1 KO slices revealed reduced frequencies of miniature excitatory- and inhibitory-postsynaptic currents, increased paired-pulse ratios and decreased input–output curves of evoked signa…
5G IoT system for real-time psycho-acoustic soundscape monitoring in smart cities
In Next-Generation Technologies, the monitoring of environmental noise nuisance in the Smart City should be as efficient as possible. 5G IoT systems offer a great opportunity to offload the node calculation, as they provide a number of new concepts for dynamic computing that previous technologies did not offer. In this case, a complete 5G IoT system for psycho-acoustic monitoring has been implemented using different options to offload the calculation of the parameters to different parts of the system. This offloading has been implemented by directly computing the metrics in the node (as a Raspberry Pi), and in a ESP32 device (FiPy) and by sampling the audio and sending it to the EDGE in the…
UWSIO: Towards automatic orchestration for the deployment of 5G monitoring services from bare metal
The next generation mobile networks 5G are currently being intensively developed and standardized globally, with commercial prototyping 5G connections already emerging. At the 5G system level, one of the Key Performance Indicators (KPIs) defining 5G is substantially reduced service creation time for 5G network operators and/or service providers to increase the system efficiency and thus reduce operational costs. In this work, we focus on realize this challenging KPI in terms of speedy creation of monitoring services for 5G operators from scratch (no operating system pre-installed). A new 5G infrastructure orchestrator UWSIO is proposed to achieve fully automated deployment of 5G monitoring …
N-Acyl-glutarimides: Effect of Glutarimide Ring on the Structures of Fully Perpendicular Twisted Amides and N–C Bond Cross-Coupling
N-Acyl-glutarimides have emerged as the most reactive precursors for N-C(O) bond cross-coupling reactions to date, wherein the reactivity is driven by ground-state destabilization of the amide bond. Herein, we report a full study on the effect of a glutarimide ring on the structures, electronic properties, and reactivity of fully perpendicular N-acyl-glutarimide amides. Most notably, this report demonstrates the generality of deploying N-acyl-glutarimides to achieve full twist of the acyclic amide bond, and results in the discovery of N-acyl-glutarimide amide with an almost perfect twist value, τ = 89.1°. X-ray structures of five new N-acyl-glutarimides are reported. Reactivity studies in t…
Chiral excitations of magnetic droplet solitons driven by their own inertia
The inertial effects of magnetic solitons play a crucial role in their dynamics and stability. Yet governing their inertial effects is a challenge for their use in real devices. Here, we show how to control the inertial effects of magnetic droplet solitons. Magnetic droplets are strongly nonlinear and localized autosolitons than can form in current-driven nanocontacts. Droplets can be considered as dynamical particles with an effective mass. We show that the dynamical droplet bears a second excitation under its own inertia. These excitations comprise a chiral profile, and appear when the droplet resists the force induced by the Oersted field of the current injected into the nanocontact. We …
5th International Symposium on Focused Ultrasound
Introduction Breast fibroadenomata (FAD) are benign lesions which occur in about 10 % of all women. Diagnosis is made by triple assessment (physical examination, imaging and/or histopathology/cytology). For a definitive diagnosis of FAD, the treatment is conservative unless the patient is symptomatic. For symptomatic patients, the lumps can be surgically excised or removed interventionally by vacuum-assisted mammotomy (VAM). Ablative techniques like high-intensity focused ultrasound (HIFU), cryo-ablation and laser ablation have also been used for the treatment of FAD, providing a minimally invasive treatment without scarring or poor cosmesis. This review summarises current trials using mini…
An endophytic bacillus subtilis strain protects grapevine against downy mildew by direct effect and defense stimulation
National audience; Plasmopara viticola, the causal agent of grapevine downy mildew, is one of the most devastating grape pathogen. Phytochemicals are generally used to control infections, but the appearance of resistant strains and the concern for possible adverse effects on environment and human health are increasing the search for alternative strategies. Biological control has received a great deal of attention as an alternative and promising measure to control different plant diseases. Many antagonistic microorganisms, including Bacillus spp., have been exploited against different pathogens. Bacillus spp. activity results from multiple modes of action including antibiosis, competition, a…
Evaluation of Cyclic Amides as Activating Groups in N-C Bond Cross-Coupling: Discovery of N-Acyl-δ-valerolactams as Effective Twisted Amide Precursors for Cross-Coupling Reactions
The development of efficient methods for facilitating N-C(O) bond activation in amides is an important objective in organic synthesis that permits the manipulation of the traditionally unreactive amide bonds. Herein, we report a comparative evaluation of a series of cyclic amides as activating groups in amide N-C(O) bond cross-coupling. Evaluation of N-acyl-imides, N-acyl-lactams, and N-acyl-oxazolidinones bearing five- and six-membered rings using Pd(II)-NHC and Pd-phosphine systems reveals the relative reactivity order of N-activating groups in Suzuki-Miyaura cross-coupling. The reactivity of activated phenolic esters and thioesters is evaluated for comparison in O-C(O) and S-C(O) cross-c…
Nitric Oxide/Cyclic Guanosine Monophosphate Signaling via Guanylyl Cyclase Isoform 1 Mediates Early Changes in Synaptic Transmission and Brain Edema Formation after Traumatic Brain Injury.
Traumatic brain injury (TBI) often induces structural damage, disruption of the blood-brain barrier (BBB), neurodegeneration, and dysfunctions of surviving neuronal networks. Nitric oxide (NO) signaling has been suggested to affect brain functions after TBI. The NO exhibits most of its biological effects by activation of the primary targets-guanylyl cyclases (NO-GCs), which exists in two isoforms (NO-GC1 and NO-GC2), and the subsequently produced cyclic guanosine monophosphate (cGMP). However, the specific function of the NO-NO-GCs-cGMP pathway in the context of brain injury is not fully understood. To investigate the specific role of the isoform NO-GC1 early after brain injuries, we perfor…
5G IoT System for Real-Time Psycho-Acoustic Soundscape Monitoring in Smart Cities With Dynamic Computational Offloading to the Edge
Environmental noise monitoring for smart cities need to be as much efficient as possible in order to mitigate its significant impact in the health of their inhabitants. 5G Internet of Things (IoT) systems offer a big opportunity to offload the computation from the sensor nodes, since it provides a series of new concepts for dynamic computing that the previous technologies did not offer. In this article, a complete 5G IoT system for psycho-acoustic monitoring has been designed and implemented using different options for offloading computation to different parts of the system. This offloading has been done by developing different functional splittings of the psycho-acoustic metrics algorithms…
Adaptive Mechanisms of Somatostatin-Positive Interneurons after Traumatic Brain Injury through a Switch of α Subunits in L-Type Voltage-Gated Calcium Channels
Abstract Unilateral traumatic brain injury (TBI) causes cortical dysfunctions spreading to the primarily undamaged hemisphere. This phenomenon, called transhemispheric diaschisis, is mediated by an imbalance of glutamatergic versus GABAergic neurotransmission. This study investigated the role of GABAergic, somatostatin-positive (SST) interneurons in the contralateral hemisphere 72 h after unilateral TBI. The brain injury was induced to the primary motor/somatosensory cortex of glutamate decarboxylase 67–green fluorescent protein (GAD67-GFP) knock-in mice at postnatal days 19–21 under anesthesia in vivo. Single GFP+ interneurons of the undamaged, contralateral cortex were isolated by fluores…
NFVMon: Enabling Multioperator Flow Monitoring in 5G Mobile Edge Computing
With the advances of new-generation wireless and mobile communication systems such as the fifth-generation (5G) mobile networks and Internet of Things (IoT) networks, demanding applications such as Ultra-High-Definition video applications is becoming ever popular. These applications require real-time monitoring and processing to meet the mission-critical quality of service requirements and are expected to be supported by the emerging fog or edge computing paradigms. This paper presents NFVMon, a novel monitoring architecture to enable flow monitoring capabilities of network traffic in a 5G multioperator mobile edge computing environment. The proposed NFVMon is integrated with the management…
CCDC 1969088: Experimental Crystal Structure Determination
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 2082397: Experimental Crystal Structure Determination
Related Article: Md. Mahbubur Rahman, Daniel J. Pyle, Elwira Bisz, Bażej Dziuk, Krzysztof Ejsmont, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2021|J.Org.Chem.|86|10455|doi:10.1021/acs.joc.1c01110
CCDC 1969085: Experimental Crystal Structure Determination
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 1969087: Experimental Crystal Structure Determination
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 1969082: Experimental Crystal Structure Determination
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227
CCDC 1969086: Experimental Crystal Structure Determination
Related Article: Md. Mahbubur Rahman, Chengwei Liu, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Qi Wang, Hao Chen, Roman Szostak, Michal Szostak|2020|J.Org.Chem.|85|5475|doi:10.1021/acs.joc.0c00227