0000000000881402

AUTHOR

C Sayehli

showing 3 related works from this author

Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption

2003

Placental abruption is an unpredictable severe complication in pregnancy. In order to investigate the possibility that the activation of the fetal nonadaptive immune system may be involved in the pathogenesis of this disease, IL-6 release from cord blood monocytes was examined by intracellular cytokine staining and flow cytometric analysis. Our results demonstrate that preterm placental abruption (n = 15) in contrast to uncontrollable preterm labor (n = 33) is associated with significantly (P < 0.001) increased release of IL-6 from the fetal monocytes. The same holds true for rhesus disease (n = 9, P < 0.001) that is characterized by a maternal production of antibodies against the rhesus-D …

Time FactorsImmunologyAntibodiesMonocytesPreeclampsiaPathogenesisFetusObstetric Labor PrematureImmune systemHLA AntigensPregnancyHumansImmunology and AllergyMedicineAbruptio PlacentaeFetusPregnancybiologyPlacental abruptionbusiness.industryImmunityFetal Bloodmedicine.diseaseFetal circulationImmunologybiology.proteinFemaleAntibodybusinessClinical Immunology
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Spontaneous labour at term is associated with fetal monocyte activation.

1999

SUMMARYThe aetiology of both term and preterm labour remains incompletely understood. Maternal infectious diseases as well as intra-uterine infections were shown to be a well established cause of uncontrollable preterm delivery, indicating that inflammatory reactions, regulated by maternal immunecompetent cells, are implicated in labour-promoting mechanisms. To investigate the possibility that the activation of the fetal immune system may be involved in labour induction, we examined cytokine production patterns of different cord blood cell populations obtained from neonates after spontaneous onset of normal term labour and vaginal delivery (n = 25), vaginal delivery but induced term labour …

medicine.medical_treatmentT cellImmunologyInflammationGestational AgeBetamethasoneMonocytesMagnesium SulfateImmune systemFetusObstetric Labor PrematurePregnancymedicineImmunology and AllergyHumansLabor InducedLungreproductive and urinary physiologyFenoterolFetusLabor Obstetricbusiness.industryVaginal deliveryCesarean SectionInterleukin-6MonocyteInfant NewbornDelivery ObstetricFetal Bloodmedicine.anatomical_structureCytokineTocolytic AgentsCord bloodImmunologyFemaleOriginal Articlemedicine.symptombusinessClinical and experimental immunology
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Preeclampsia, a pregnancy-specific disease, is associated with fetal monocyte activation.

2001

The maternal syndrome of preeclampsia is an exclusively pregnancy-related illness involving multiple organs and severe forms may be complicated by HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. Recently, it has been proposed that both normal pregnancy and preeclampsia are associated with a systemic activation of the nonspecific maternal immune system and that, in particular, monocytes have a central role in the adjustment of maternal immune functions in pregnancy. Here we have investigated the role of the fetal nonadaptive immune system in normal term delivery, uncontrollable preterm labor, and preeclampsia. We demonstrate that spontaneous delivery at term as well as pre…

medicine.medical_specialtyHELLP SyndromeHELLP syndromeImmunologyLipopolysaccharide ReceptorsInflammationBiologyMonocytesPreeclampsiaImmune systemFetusPre-EclampsiaPregnancyInternal medicinemedicineImmunology and AllergyHumansreproductive and urinary physiologyFetusPregnancyInnate immune systemInterleukin-6MonocyteHistocompatibility Antigens Class IHistocompatibility Antigens Class IImedicine.diseaseFetal BloodEndocrinologymedicine.anatomical_structureembryonic structuresImmunologyFemalemedicine.symptomClinical immunology (Orlando, Fla.)
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