0000000000886823

AUTHOR

Alfredo Pulvirenti

showing 8 related works from this author

Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-an…

2018

Background Internal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes. Objective To assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies. Methods PubMed, Medline, Web of Science, Embase databases, and the Cochrane Library were searched up to April 2018 to identify studies that compared primary vitrectomy with and without ILM peeling for RRD with at least six m…

Genetics and Molecular Biology (all)Visual acuitygenetic structuresVisionmedicine.medical_treatmentVisual Acuitylcsh:MedicineSocial SciencesVitrectomyBiochemistrylaw.inventionDatabase and Informatics Methods0302 clinical medicineMathematical and Statistical TechniquesPostoperative ComplicationsRandomized controlled trialBiochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)lawVitrectomyMedicine and Health SciencesPsychology030212 general & internal medicineDatabase Searchinglcsh:ScienceMultidisciplinaryOphthalmic ProceduresRetinal detachmentEpiretinal MembraneResearch AssessmentMeta-analysisPhysical SciencesRetinal DisordersSensory PerceptionEpiretinal membranemedicine.symptomAnatomyStatistics (Mathematics)HumanResearch Articlemedicine.medical_specialtySystematic ReviewsSurgical and Invasive Medical ProceduresResearch and Analysis Methods03 medical and health sciencesOcular SystemOphthalmologymedicineHumansStatistical MethodsBiochemistry Genetics and Molecular Biology (all)Primary vitrectomybusiness.industryInternal limiting membranelcsh:RRetinal DetachmentBiochemistry; Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)Biology and Life Sciencesmedicine.diseaseeye diseasesbody regionsOphthalmologyAgricultural and Biological Sciences (all)030221 ophthalmology & optometryEyeslcsh:QPostoperative Complicationsense organsbusinessHeadMathematicsMeta-AnalysisNeuroscience
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POOLED ESTIMATES OF INCIDENCE OF ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS WITH AND WITHOUT TOPI…

2017

Purpose: To assess the effect of topical antibiotic prophylaxis on postoperative endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents.Methods: A systematic literature search was performed from inception to March 2016 using PubMed, Medline, Web of Science, Embase, and the Cochrane Library, to identify articles that reported cases of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. We used a pooled analysis to estimate the incidence of cases of endophthalmitis who developed after injections performed with and without topical antibiotic prophylaxis. We used regression analysis to explore the effects of stu…

Vascular Endothelial Growth Factor Amedicine.medical_specialtyEye InfectionsVisual AcuityAntibiotic prophylaxis; Anti–vascular endothelial growth factor; Endophthalmitis; Intravitreal injection;Angiogenesis InhibitorsCochrane LibraryGlobal HealthEye Infections Bacteriallaw.invention03 medical and health sciencestopical antibiotic prophylaxis; postoperative endophthalmitis; anti–vascular endothelial growth factor agents; intravitreal injectionpostoperative endophthalmitis0302 clinical medicineEndophthalmitisRandomized controlled triallawtopical antibiotic prophylaxisanti–vascular endothelial growth factor agentsInternal medicinemedicineantibiotic prophylaxiHumansanti-vascular endothelial growth factor030212 general & internal medicineAntibiotic prophylaxisProspective cohort studyAntibiotic prophylaxis; Anti–vascular endothelial growth factor; Endophthalmitis; Intravitreal injection; Angiogenesis Inhibitors; Anti-Bacterial Agents; Endophthalmitis; Eye Infections Bacterial; Global Health; Humans; Intravitreal Injections; Vascular Endothelial Growth Factor A; Antibiotic Prophylaxis; Visual AcuityEndophthalmitisbusiness.industryIncidence (epidemiology)Bacterialintravitreal injectionRetrospective cohort studyGeneral MedicineEye infectionAntibiotic Prophylaxismedicine.diseaseAntibiotic prophylaxis; Anti–vascular endothelial growth factor; Endophthalmitis; Intravitreal injection; Angiogenesis Inhibitors; Anti-Bacterial Agents; Endophthalmitis; Eye Infections; Bacterial; Global Health; Humans; Intravitreal Injections; Vascular Endothelial Growth Factor A; Antibiotic Prophylaxis; Visual AcuitySurgeryAnti-Bacterial AgentsOphthalmologyendophthalmitiIntravitreal Injections030221 ophthalmology & optometryAnti–vascular endothelial growth factorbusiness
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Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational…

2022

Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality rate of COVID-19 continues to rise across the world. Data regarding predictors of mortality in patients with COVID 19 are still scarce but are being actively investigated. The present multi…

predictors of death.SARS-CoV-2General Neurosciencepandemicepidemiological featuresGeneral MedicineGeneral Pharmacology Toxicology and Pharmaceuticsepidemiological featureSARS-CoV-2 pandemic epidemiological features predictors of deathpredictors of deathGeneral Biochemistry Genetics and Molecular Biology
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Intravitreal anti-vascular endothelial growth factors, panretinal photocoagulation and combined treatment for proliferative diabetic retinopathy: a s…

2020

Purpose: to conduct a systematic review with network meta‐analysis (NMA) of randomized clinical trials (RCTs) comparing panretinal photocoagulation (PRP) versus anti‐vascular endothelial growth factor (VEGF) treatment alone or in combination with PRP, for proliferative diabetic retinopathy (PDR).Methods: PubMed, Medline and Embase databases were searched for RCTs comparing PRP versus intravitreal anti‐VEGF therapy and/or combined PRP and intravitreal anti‐VEGF for PDR. The primary outcome measures were the mean best corrected visual acuity (BCVA) change and the regression of neovascularization. Mean change of central macular thickness (CMT), the subgroup analyses of patients without diabeti…

medicine.medical_specialtyBevacizumabgenetic structurespegaptanibmedicine.medical_treatmentPegaptanibNetwork Meta-AnalysisVisual AcuityVitrectomyAngiogenesis Inhibitorsbevacizumablaw.inventionNeovascularization03 medical and health sciences0302 clinical medicineRandomized controlled trialaflibercept; bevacizumab; intravitreal anti-VEGF; panretinal photocoagulation; pegaptanib; proliferative diabetic retinopathy; ranibizumabintravitreal anti-VEGFlawOphthalmologyVitrectomymedicineHumansranibizumabAfliberceptDiabetic RetinopathyLaser Coagulationbusiness.industryafliberceptGeneral MedicineDiabetic retinopathymedicine.diseasepanretinal photocoagulationeye diseasesOphthalmologyIntravitreal Injections030221 ophthalmology & optometrysense organsRanibizumabmedicine.symptombusiness030217 neurology & neurosurgerymedicine.drugproliferative diabetic retinopathy
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Treat and extend versus fixed regimen in neovascular age related macular degeneration: A systematic review and meta-analysis

2020

Purpose: To compare efficacy of treat and extend (T&E) versus fixed regimen treatment protocols in neovascular age-related macular degeneration (nAMD). Methods: Randomized clinical trials (RCTs) comparing T&E versus fixed regimen protocols for nAMD were systematically searched. Primary outcome was to compare the mean best corrected visual acuity (BCVA) change in T&E regimen versus fixed regimen. Secondary outcomes were change in the mean optical coherence tomography (OCT) central retinal thickness (CRT) and mean number of injections. Standardized mean difference (SMD) along with 95% confidence intervals (CIs) were calculated. Random-effect models were used for meta-analyses. Res…

Vascular Endothelial Growth Factor Amedicine.medical_specialtyretinaretinal pathology/researchVisual AcuityAngiogenesis InhibitorsTreat and extendlaw.inventionMacular DegenerationRandomized controlled trialClinical Protocolsretina – medical therapieslawInternal medicineAge relatedRanibizumabMedicineHumansbusiness.industryAge-related macular degenerationGeneral MedicineMacular degenerationpediatric ophthalmologyretina – medical therapiemedicine.diseaseOphthalmologyRegimenTreatment OutcomeMeta-analysisvitreous/retinal diseaseIntravitreal InjectionsWet Macular DegenerationPediatric ophthalmologypharmacologybusinessTomography Optical CoherenceAge-related macular degeneration; pediatric ophthalmology; pharmacology; retina; retina – medical therapies; retinal pathology/research; vitreous/retinal disease
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Geo-Epidemiology of Age-Related Macular Degeneration: New Clues Into the Pathogenesis

2015

Abstract PURPOSE: To evaluate the demographic, geographic, and race-related variables that account for geographic variability in prevalence rates of age-related macular degeneration (AMD). DESIGN: Systematic review, meta-regression, and decision-tree analysis. METHODS: A systematic literature review of PubMed, Medline, Web of Science, and Embase databases identified population-based studies on the prevalence of AMD published before May 2014. Only population-based studies that took place in a spatially explicit geographic area that could be geolocalized, and used retinal photographs and standardized grading classifications, were included. Latitude and longitude data (geolocalization) and the…

Malemedicine.medical_specialtygenetic structuresPopulationPrevalenceGlobal HealthPrevalence of AMDLatitude03 medical and health sciencesMacular Degeneration0302 clinical medicineAge DistributionRisk FactorsEpidemiologymedicinePrevalenceHumans030212 general & internal medicineSex DistributioneducationAgedAged 80 and overeducation.field_of_studyGeoepidemiologyGeographySettore MED/30 - Malattie Apparato VisivoDecision TreesRegression analysisBayes TheoremMiddle Agedeye diseasesOphthalmologyGeographySystematic reviewAge-Related Macular DegenerationMeta-analysis030221 ophthalmology & optometryFemalesense organsLongitudeDemography
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Risk of Death Associated With Intravitreal Anti-Vascular Endothelial Growth Factor Therapy: A Systematic Review and Meta-analysis.

2020

Importance Although intravitreal anti–vascular endothelial growth factor (VEGF) treatment represents the first-line therapy for many retinal diseases, the issue of their systemic safety is debatable. Objectives To assess whether intravitreal anti-VEGF therapy might be associated with increased risk of mortality and which variables are associated with the increase. Data Sources PubMed, MEDLINE, and Embase databases, the Cochrane Library, and ClinicalTrials.gov were systematically searched from inception to May 6, 2019. Study Selection Randomized clinical trials comparing intravitreal anti-VEGF treatment with control groups and with follow-up of at least 6 months were selected. Data Extractio…

Vascular Endothelial Growth Factor Amedicine.medical_specialtyDatabases FactualMEDLINEAngiogenesis InhibitorsCochrane LibraryMacular Edemalaw.inventionRandomized controlled triallawFrequentist inferenceInternal medicineCause of DeathRetinal Vein OcclusionMedicineHumansanti-VEGF therapyrisk of mortality anti-vascular endothelial growth factor mortalityCause of deathOriginal InvestigationRandomized Controlled Trials as TopicDiabetic Retinopathybusiness.industryMortality rateOdds ratioChoroidal NeovascularizationOphthalmologyMeta-analysisIntravitreal InjectionsWet Macular DegenerationbusinessJAMA ophthalmology
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Supplementary_material – Supplemental material for Treat and extend versus fixed regimen in neovascular age related macular degeneration: A systemati…

2020

Supplemental material, Supplementary_material for Treat and extend versus fixed regimen in neovascular age related macular degeneration: A systematic review and meta-analysis by Matteo Fallico, Andrew J Lotery, Antonio Longo, Teresio Avitabile, Vincenza Bonfiglio, Andrea Russo, Nicolò Castellino, Guglielmo Parisi, Alfredo Pulvirenti, Chiara Eandi, Gilda Cennamo, Claudio Furino, Maria Vittoria Cicinelli, Camilla Alovisi and Michele Reibaldi in European Journal of Ophthalmology

Medicine
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