0000000000887048

AUTHOR

S V Petrov

showing 1 related works from this author

Defining Ewing and Ewing-like small round cell tumors (SRCT): The need for molecular techniques in their categorization and differential diagnosis. A…

2016

Abstract Background Differentiation of Ewing sarcoma family of tumors (ESFT) and Ewing-like tumors remains problematic. Certain ESFT with morphological and immunohistochemical (IHC) profiles lack the EWSR1-ETS transcript. To improve diagnostic accuracy we investigated the presence of several specific transcripts in 200 small round cell tumors (SRCT) displaying ESFT morphology and immunophenotype in which EWSR1 FISH analysis was non-informative or negative. Design 200 tumors (formalin-fixed, paraffin-embedded) were analyzed by RT-PCR. All tumors were tested for EWSR1-ETS , EWSR1 / WT1 , PAX3 / 7-FOX01 or SYT / SSX transcripts, and the negative tumors were subsequently analyzed for CIC / DUX4…

0301 basic medicinePathologymedicine.medical_specialtyOncogene Proteins FusionDesmoplastic small-round-cell tumorCD99Sarcoma EwingBiologyTranslocation GeneticPathology and Forensic MedicineDiagnosis DifferentialFusion gene03 medical and health sciences0302 clinical medicineImmunophenotypingBiomarkers TumormedicineHumansPathology MolecularIn Situ Hybridization FluorescenceRNA-Binding ProteinsGeneral Medicinemedicine.diseaseSynovial sarcoma030104 developmental biology030220 oncology & carcinogenesisSarcoma Small CellImmunohistochemistryCalmodulin-Binding ProteinsSarcomaRNA-Binding Protein EWSDifferential diagnosisAnnals of Diagnostic Pathology
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