Author: Xiangyu Chen

0000000000892512

AUTHOR

Xiangyu Chen

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N-Heterocyclic Carbene Catalyzed Asymmetric Synthesis of Pentacyclic Spirooxindoles via [3+3] Annulations of Isatin-Derived Enals and Cyclic N-Sulfon…

2019

A convenient enantioselective route to new types of pentacyclic spirooxindoles via [3+3] annulation reactions of isatin-derived enals and cyclic N-sulfonyl ketimines, using N-heterocyclic carbene (NHC) catalysis has been developed. The new protocol leads to pentacyclic spirooxindoles bearing a quaternary spirostereocenter in good yields and good to high enantiomeric ratios. peerReviewed

kemiallinen synteesiisatin-derived enalsasymmetric synthesisN-heterocyclic carbenespentacyclic spirooxindolescyclic ketiminesorgaaniset yhdisteet

researchProduct

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