0000000000894246
AUTHOR
Haim I. Bicher
HETEROGENEOUS OXYGEN TRANSPORT WITHIN MALIGNANT TUMORS
Publisher Summary This chapter discusses the heterogeneous oxygen transport within malignant tumors. Many solid tumors disturbances in the vascularization and in the microcirculation generally lead to distinct restrictions in the convective and diffusive transport. Beyond that, a heterogeneous distribution of the transport conditions develops causing an insufficient and heterogeneous substrate supply as well as an inadequate drainage of wastes. As one of the compulsory manifestations, a poor and heterogeneous oxygen supply becomes more extensively evident with increasing tumor size or age. The polarographic measurements of the local tissue pO 2 values in animal tumors show that very low oxy…
TISSUE OXYGENATION AND NORMAL AND HYPERTHERMIC CONDITIONS
Publisher Summary This chapter describes the tissue oxygenation and normal and hyperthermic conditions. The knowledge of the effect of hyperthermia on tumor and normal tissue blood flow is important not only for the effect of hyperthermia on hypoxic cells at the time of radiation, but also for differential tumor heating. There is considerable evidence from plethsmography that an elevation of normal tissue temperature to 41°C is accompanied by a considerable increase in blood flow. The chapter discusses studies that were conducted to examine changes in the microenvironment of normal and tumor tissue as measured directly with ultramicroelectrodes. In situ studies were carried out in fourth ge…