0000000000899347
AUTHOR
Cristina Prinzivalli
showing 24 related works from this author
Diorganotin(IV) N-acetyl-L-cysteinate complexes: synthesis, solid state, solution phase, DFT and biological investigations.
2009
Diorganotin(IV) complexes of N-acetyl-L-cysteine (H(2)NAC; (R)-2-acetamido-3-sulfanylpropanoic acid) have been synthesized and their solid and solution-phase structural configurations investigated by FTIR, Mössbauer, (1)H, (13)C and (119)Sn NMR spectroscopy. FTIR results suggested that in R(2)Sn(IV)NAC (R = Me, Bu, Ph) complexes NAC(2-) behaves as dianionic tridentate ligand coordinating the tin(IV) atom, through ester-type carboxylate, acetate carbonyl oxygen atom and the deprotonated thiolate group. From (119)Sn Mössbauer spectroscopy it could be inferred that the tin atom is pentacoordinated, with equatorial R(2)Sn(IV) trigonal bipyramidal configuration. In DMSO-d(6) solution, NMR spectr…
Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: a novel and potential appr…
2013
Three new triorganotin(IV) complexes of valproic acid (vp1, Me3Sn-valproate; vp2, Bu3Sn-valproate; vp3, Ph3Sn-valproate) have been synthesized and investigated by spectroscopic and biological methods. An anionic, monodentate valproate ligand was observed, ester-like coordinating the tin atom on a tetra-coordinated, monomeric environment. The structures, though, can distort towards a penta-coordination, as a consequence of a long range O center dot center dot center dot Sn interaction. Crystallographic and NMR findings confirm this situation both in solid state and solution. Biological finding evidenced a clear cytotoxic action of the complexes in hepatocellular carcinoma cell cultures: one …
Syntesis, characterization and electrochemistry of Ru(III) complexes with several aminoacid ligands
2007
Synthesis, structure and electrochemistry of ruthenium(III) complexes whith potential biological activity
2007
USO TERAPEUTICO COMBINATO DI ORGANOSTAGNO(IV) ED INIBITORI DELLE DEACETILASI ISTONICHE
2010
New Ruthenium complexes with antitumoral activity
2006
Synthesis, Structural characterization and Exafs investigations of new ruthenium(III) complexes.
2008
Two new complexs of Ru(III) with glucosaminic acid and 1-Methyluracil, [RuCl2(Glun-N,O)2]H (I), (Glun-= glucosaminate); [RuCl4(1-MeU-N3)(DMSO)]H2.H2O (II), (1-MeU-= 1-Methyluracilate) were prepared from the same Ru(III) precursors, RuCl3•3H2O and [(DMSO)2H][trans-RuCl4(DMSO)2]. The characterization of the complexes have been carried out by elemental analysis, FT-IR, ES-MS, NMR and EXAFS.
How organotin(IV)(sulfonatophenyl) porphynate may activate the apoptotic pathways in melanoma cells?
2006
Bu2Sn(N-acetyl-L-cysteinate) antitumor activity on HepG2 cells
2010
ORGANOSTAGNO(IV) COMPLESSI CON N-ACETILCISTEINA AD ATTIVITÀ ANTITUMORALE, PROCEDIMENTO PER LA LORO PRODUZIONE E LORO USO.
2008
Organotin(IV) and simple fatty acids: preliminary assessments
2012
Our group has a long researching tradition in the field of organotin(IV) complexes, usually proposed and tested as potential anti-tumor drugs. The leitmotif has usually been the modulation of the intrinsic toxicity/cytotoxicity of the organometallic moiety and a modulation of the toxic effect by means of biologically related molecules (synthetic or natural). Such a modulation is usually achieved by two (often overlapping) routes: dampen the damaging effects of the metal core, and serving as a carrier for specific tissue districts. Since a too tight binding on the organotin moiety is not always desirable – a too much stable complex could be a non-active one – carboxylates have always played …
Dibuthyltin(IV) Complexes with Caffeic acid: Apoptotic Effect on human cancer cells
2013
Carbocysteine degradation catalyzed by organotin(IV) compounds.
2008
Novel metallic and organometallic based antiproliferative complexes: Integrated methodologies of evaluation
2005
ATTIVITÀ CITOTOSSICA DEI COMPLESSI DIORGANOSTAGNO(IV)-N-ACETILCISTEINA SU CELLULE DI MELANOMA A-375.
2005
Synthesis, structural investigation and biological activity of metal ions complexes of N-acetylcysteine and carbocysteine
2006
Complessi di nuova sintesi di derivati della cisteina con ioni metallici
2006
Synthesis and characterization of diorganotin(IV)complexes with Phenothiazine class Drugs. Biological and Theoretical studies on cytotoxic activity
2005
Studi strutturali e indagini biologiche di nuovi complessi di rutenio(III) con 1- tioglucosio e 1-metiluracile
2006
Computational studies of new metallic ions complexes of antioxidant dipeptides
2005
Synthesis and characterization of some new ruthenium complexes with ligands of biological interest
2005
Synthesis, structural investigation and biological activity of new diorganotin(IV) N-acetylcysteine Complexes.
2006
Organometallic Complexes with Biological Molecules. Structural investigation of cis-diammineplatinum(II)-Porphyrin derivatives.
2009
CCDC 830010: Experimental Crystal Structure Determination
2013
Related Article: Ornella Pellerito, Cristina Prinzivalli, Elisabetta Foresti, Piera Sabatino, Michele Abbate, Girolamo Casella, Tiziana Fiore, Michelangelo Scopelliti, Claudia Pellerito, Michela Giuliano, Giulia Grasso, Lorenzo Pellerito|2013|J.Inorg.Biochem.|125|16|doi:10.1016/j.jinorgbio.2013.04.008