Cytotoxic lymphocytes show reduced expression of cd94/NKG2A and perforin in malignant pleural effusions

Comparision Between the Expression of Innate Immunity and Coagulative Response in Patients with septic and No Septic Acute Lung Injury

The Role of Natural Ventilative Cooling in NZE Temporary and Emergency Shelters Design: a Mediterranean Case Study

The paper presents a case-study of a pre-fabricated housing module built in Messina (Sicily, Italy) and the assessment of its energy performances under the net zero energy perspective. The potential of ventilative natural cooling application in the case-study is also investigated. Some particular features of the building - the modularity, the prefabrication, the rapidity of assembly, the possibility of being built on disconnected soils and the absence of maintenance - identify an effective use as a temporary housing solution for e.g. workers in proximity of an isolated working place or in emergency situations such as earthquakes and natural disasters. Monitoring studies were performed durin…

“Smoke, Choline-Acetyl-Transferase, Muscarinic Receptors and fibroblast proliferation in COPD

Acetylcholine (ACh), synthesized by choline acetyltransferase (ChAT), and muscarinic M1, M2, and M3 receptors (MRs) are involved in fibroblast proliferation. We evaluated ChAT, MRs, and extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor (NF) κB activation in lung fibroblasts from patients with chronic obstructive pulmonary disease (COPD), control smokers, and controls. Human fetal lung fibroblasts (HFL-1) stimulated with interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and cigarette smoke extracts (CSEs) were evaluated for ChAT and MR expression. We tested the effects of ACh on fibroblast proliferation and its ability to bind fibroblasts from patients with COPD, control s…

Correction to: Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study.

Correction to: Internal and Emergency Medicine (2018) 13:651–660 https://doi.org/10.1007/s11739-018-1835-9 In the original publication, one of the ARAPACIS collaborators Dr. “Leonardo Di Gennaro” name has been erroneously mentioned as “Leonardo De Gennaro”.

La LCA di sistemi di accumulo impiegati nel settore edile

L’edilizia è uno dei settori più rilevanti in termini di produzione di ricchezza e di occupazione, ma è anche responsabile di significativi consumi di risorse naturali e impatti ambientali. Si stima, infatti, che nell’Unione Europea l’edilizia sia responsabile del 50÷60% del consumo di risorse naturali, e tali percentuali sono destinate ad aumentare senza l’avvio di strategie e azioni orientate alla riduzione dei consumi di combustibili fossili e alla promozione delle risorse rinnovabili. Per migliorare l’eco-profilo del settore edile, la riduzione del consumo di risorse e la minimizzazione degli impatti ambientali negli ultimi anni costituiscono gli obiettivi principali da perseguire nella…

Frailty as the Future Core Business of Public Health: Report of the Activities of the A3 Action Group of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA)

Background: The prevalence of frailty at population-level is expected to increase in Europe, changing the focus of Public Health. Here, we report on the activities of the A3 Action Group, focusing on managing frailty and supporting healthy ageing at community level. Methods: A three-phased search strategy was used to select papers published between January 2016 and May 2018. In the third phase, the first manuscript draft was sent to all A3-Action Group members who were invited to suggest additional contributions to be included in the narrative review process. Results: A total of 56 papers were included in this report. The A3 Action Group developed three multidimensional tools predicting sho…

Cigarette smoke increases TLR4 and modifies LPS mediated responses in airway epithelial cells.

Airway epithelium is emerging as a regulator of innate immune responses to a variety of insults including cigarette smoke. The main goal of this study was to explore the effects of cigarette smoke extracts (CSE) on Tolllike receptor (TLR) expression and activation in a human bronchial epithelial cell line (16-HBE). The CSE increased the expression of TLR4 and the lipopolysaccharide (LPS) binding, the nuclear factor-jB (NF-jB) activation, the release of interleukin-8 (IL-8) and the chemotactic activity toward neutrophils. It did not induce TLR2 expression or extracellular signal-regulated signal kinase 1/2 (ERK1/2) activation. The LPS increased the expression of TLR4 and induced both NF-jB a…

Pleural Mesothelial Cells Express Both BLT2 and PPAR and Mount an Integrated Response to Pleural Leukotriene B4

Leukotriene B(4) (LTB(4)) plays a crucial role in the recruitment of neutrophils into the pleural space. We identified for the first time the mechanisms by which LTB(4) interacts with mesothelial cells and recruits neutrophils in the pleural compartment. Primary pleural mesothelial cells express both the proinflammatory receptor for LTB(4) BLT2, and the anti-inflammatory receptor for LTB(4), PPARalpha. Parapneumonic pleural effusions highly increase BLT2 expression and, via BLT2 activation, increase the adhesion between mesothelial cells and neutrophils and the expression of ICAM-1 on mesothelial cells. The block of PPARalpha further increases both cell adhesion and ICAM-1 expression. BLT2 …

A multi-technique approach to study fish diversity associated with off-shore platforms.

Comparison of fishery methods for the study of fish diversity associated with off-shore platforms.

NLC Containing Fluticasone Propionate for Inhalatory Delivery: Biocompatibility and Drug Antiinflamatory Effect