Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene) modified electrode

Abstract In this study, we have explored the potentiality of using GOx/AuNP/PEDOT(BSA)/Pt electrode as an implantable, long-lasting, and sensitive glucose biosensor. We have examined the performance of the electrode for glucose calibration with three electrochemical measurements, such as cyclic voltammetry, linear sweep voltammetry, as well as chronoamperometry, which all exhibited strong linear correlation between resulting signal and glucose concentration. In comparison, linear sweep voltammetry gave the best linear sensitivity, whose average was about 3.124 µA/mM/cm2 within a wide glucose concentration range from 0.416 to 50 mM. Meanwhile, the stability of the electrode was confirmed by …