0000000000902257
AUTHOR
A. Nigro
Pruritus characteristics in a large Italian cohort of psoriatic patients
Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18 years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10 802 patients, with a mean age 48.8 ± 14.3 years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and ve…
Rejection Power of A Horizontal Rpc Telescope For Left and Right Coming Cosmic Muons
Abstract The possibility of performing neutrino astronomy by means of a detector above the ground depends critically on the feasibility of a rejection power on the order of 10 11 required to discriminate the enormous background of cosmic downward going muons from the signal of upward going muons produced by neutrinos. In order to check whether and how this rejection is obtainable, we have built in the Physics Department of the University of Bari a horizontal cosmic muon telescope (MINI) instrumented with resistive plate counters. By performing time-of-flight measurements, we have estimated the rejection power of our telescope for left and right coming cosmic muons. The rejection dependence …
Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry
Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis …