0000000000904068
AUTHOR
Carmelo Sgarlata
showing 4 related works from this author
Risedronate complexes with Mg2+, Zn2+, Pb2+, and Cu2+: Species thermodynamics and sequestering ability in NaCl(aq) at different ionic strengths and a…
2021
Abstract In this paper, potentiometry and calorimetry were used to determine the thermodynamics of interaction between risedronate and four bivalent metal cations, namely: Mg2+, Zn2+, Pb2+, and Cu2+ in aqueous NaCl solutions at different ionic strengths and at T = 298.15 K. The data analysis allowed us to ascertain that the main species formed were the MLH2, MLH, ML and M2L; however scarcely soluble species precipitated at acidic pH values, between 4 and 7 depending on the metal cation involved, probably due to the formation of the neutral M2L(s) species. Comparison of the stability constants with other similar ligands suggests that metal complexation occurs through the phosphonate with an …
Quantitative Analysis of the Interactions of Metal Complexes and Amphiphilic Systems: Calorimetric, Spectroscopic and Theoretical Aspects.
2022
Metals and metal-based compounds have many implications in biological systems. They are involved in cellular functions, employed in the formation of metal-based drugs and present as pollutants in aqueous systems, with toxic effects for living organisms. Amphiphilic molecules also play important roles in the above bio-related fields as models of membranes, nanocarriers for drug delivery and bioremediating agents. Despite the interest in complex systems involving both metal species and surfactant aggregates, there is still insufficient knowledge regarding the quantitative aspects at the basis of their binding interactions, which are crucial for extensive comprehension of their behavior in sol…
Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016
2019
Objective This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy w…
"Delirium Day": a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
2016
Background To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods This is a point prevalence study (called “Delirium Day”) including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium wa…