0000000000904699

AUTHOR

M Kayser

showing 2 related works from this author

Defining the role of common variation in the genomic and biological architecture of adult human height

2014

Item does not contain fulltext Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes…

Netherlands Twin Register (NTR)BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICAElectronic Medical Records and Genomics (eMEMERGEGE) ConsortiumMedizinGenome-wide association studyAdult; Analysis of Variance; Body Height/genetics; European Continental Ancestry Group/genetics; Genetic Variation/genetics; Genetics Population; Genome-Wide Association Study/methods; Humans; Oligonucleotide Array Sequence Analysis; Polymorphism Single Nucleotide/geneticsheritability0302 clinical medicineGenome-wideEuropean Continental Ancestry Group/geneticsSNPSOligonucleotide Array Sequence AnalysissnpsGenetics & Heredityddc:616GeneticsMedical And Health Sciences0303 health scienceseducation.field_of_studyvariantsBody Height/geneticsGENETIC-VARIATIONBiological SciencesPolymorphism Single Nucleotide/geneticsGenetic Variation/geneticsUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]Genome-Wide Association Study/methodsbody heightgenetic-variationLife Sciences & BiomedicineSingle Nucleotide/geneticsHumanAdultEuropean Continental Ancestry GroupPopulationPopulationSingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticleWhite PeopleNOcomplex traits03 medical and health sciencesGenetic variationheritability adult height/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_GeneticsHumansPolymorphismHuman heightPAGEGE ConsortiumeducationGeneVLAG030304 developmental biologyGlobal NutritionWereldvoedingAnalysis of VarianceGenome-wide; heritability; variantsgenome-wide association studyScience & TechnologyWhitesOligonucleotide Array Sequence AnalysiMUTATIONSCOMPLEX TRAITSta1184Klinisk medicinpopulation geneticsGenetic VariationHeritabilityta3121mutationsGenetic architectureBody HeightGenetics Populationgenetic variationMIGen ConsortiumInflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5]Clinical Medicine030217 neurology & neurosurgeryheightLifeLines Cohort StudyDevelopmental BiologyGenome-Wide Association StudyNature genetics
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Precision electroweak measurements on the Z resonance

2005

We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $\MZ$ and $\GZ$, and its couplings to fermions, for example the $\rho$ parameter and the effective electroweak mixing angle, are precisely measured. The number of light neutrino species is determined to be 2.9840…

Top quarkFORWARD-BACKWARD ASYMMETRYPARTICLE PHYSICS; LARGE ELECTRON POSITRON COLLIDER; ALEPH; DELPHI; L3; OPALGeneral Physics and Astronomy01 natural sciences7. Clean energyHigh Energy Physics - ExperimentSettore FIS/04 - Fisica Nucleare e SubnucleareHigh Energy Physics - Experiment (hep-ex)High Energy Physics - Phenomenology (hep-ph)electron-positron physics[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Electroweak interactionPhysicsQuantum chromodynamicsOPALElectron–positron physics; Electroweak interactions; Decays of heavy intermediate gauge bosons; Fermion–antifermion production; Precision measurements at the Z resonance; Tests of the Standard Model; Radiative corrections; Effective coupling constants; Neutral weak current; Z boson; W boson; Top quark; Higgs bosonParticle physics - ExperimentPhysicsSettore FIS/01 - Fisica SperimentaleElectroweak interactionFORWARD-BACKWARD ASYMMETRY; FERMION-PAIR PRODUCTION; HADRONIC-Z-DECAYS; TOP-QUARK MASS; ANGLE BHABHA SCATTERING; W-BOSON MASS; CROSS-SECTION ASYMMETRY; Z-LINE-SHAPE; SEMILEPTONIC BRANCHING RATIOS; CARLO EVENT GENERATORdecays of heavy intermediate gauge bosons; effective coupling constants; electron-positron physics; electroweak interactions; fermion-antifermion production; higgs boson; neutral weak current; precision measurements at the z resonance; radiative corrections; tests of the standard model; top quark; w boson; z bosonRadiative correctionsALEPHLARGE ELECTRON POSITRON COLLIDERRadiative correctionHigh Energy Physics - PhenomenologyFIS/01 - FISICA SPERIMENTALEDecays of heavy intermediate gauge bosonsL3Z-LINE-SHAPEHiggs bosonFERMION-PAIR PRODUCTIONPARTICLE PHYSICSFísica nuclearNeutrinoFermion–antifermion productionPrecision measurements at the Z resonanceTests of the Standard ModelParticle physicsZ bosonfermion-antifermion productionElectroweak interactionsHiggs bosonFOS: Physical sciencesddc:500.2Elementary particle physics ; z boson ; LEP ; electroweakDecays of heavy intermediate gauge bosonEffective coupling constantPartícules (Física nuclear)Standard ModelNeutral weak currentelectroweak theory Z boson DELPHI ALEPH OPAL L30103 physical sciencesANGLE BHABHA SCATTERINGCROSS-SECTION ASYMMETRYSEMILEPTONIC BRANCHING RATIOS010306 general physicsTOP-QUARK MASSEffective coupling constantsDELPHICoupling constantElectron–positron physics010308 nuclear & particles physicsHigh Energy Physics::PhenomenologyFermionCARLO EVENT GENERATORTop quarkW-BOSON MASSFORWARD-BACKWARD ASYMMETRY FERMION-PAIR PRODUCTION HADRONIC-Z-DECAYS TOP-QUARK MASS ANGLE BHABHA SCATTERING W-BOSON MASS CROSS-SECTION ASYMMETRY Z-LINE-SHAPE SEMILEPTONIC BRANCHING RATIOS CARLO EVENT GENERATOR[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph]Experimental High Energy PhysicsElectron–positron physicW bosonHigh Energy Physics::ExperimentFIS/04 - FISICA NUCLEARE E SUBNUCLEAREHADRONIC-Z-DECAYSPHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS
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