0000000000907984
AUTHOR
Mario Belvedere
LA DOMOTICA A FAVORE DEGLI ANZIANI
Oral Magnesium Supplementation and Endothelial Function in diabetic and Hypertensive Older Patients
I LUOGHI DELLA CURA E DEL MORIRE: REPARTO DI GERIATRIA: TRE ANNI DI ATTIVITÀ
MILD COGNITIVE IMPAIRMENT (MCI): LA ZONA GRIGIA
PREVENZIONE NELLE MALATTIE NEURODEGENERATIVE NELL’ANZIANO
DEFICIT COGNITIVO E DIABETE MELLITO. STUDIO OSSERVAZIONALE
Ecocolordoppler epiaortico e transcranico nelle diagnosi differenziale delle demenze
Intermittent intramuscular clodronate therapy: a valuable option for older osteoporotic women
222. DEPRESSIONE E M. DI PARKINSON: VALUTAZIONE DEL TONO DELL’UMORE IN 20 PAZIENTI ULTRASETTANTENNI IN TRATTAMENTO CON L-DOPA E/O DOPAMINO-AGONISTI. DATI PRELIMINARI
ANEMIA E DECLINO FUNZIONALE NELL’ANZIANO
VALUTAZIONE DELLA PERFORMANCE COGNITIVA IN PAZIENTI POST ICTUS
RIABILITAZIONE NEUROMOTORIA NELLA M. DI PARKINSON: CONDIZIONAMENTO SENSORIALE
Violenza contro le persone anziane
Abuse against elderly persons is extremely frequent, although very often is not declared, and entails high human and financial costs. There are on the whole three types of abuse including domestic, institutional, and auto inflicted. It is difficult to get enough information to define the real dimension of the problem, but data from the National Elder Abuse Incidence Study (NEAIS) describe an increasing and expanding phenomenon. The large proportions of this type of violence has lead the World Health Organization to propose strategies primarily focused on three points: Awareness, Education en Defence. An important role in the prevention and diagnosis of elderly abuse is in the hands of the p…
EFFECTS OF POLYENOIC ω-3 FATTY ACIDS ON OXIDATIVE STRESS IN HYPERTENSIVE ELDERLY SUBJECTS
MALATTIA DI PARKINSON: FATTORI AMBIENTALI E GENETICI
MAGNESIUM METABOLISM IN INSULIN RESISTENCE, METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITUS
PSEUDODEMENZA, DEPRESSIONE E DEMENZA
Effects of polyenoic omega-3 fatty acid on oxidative stress in hypertensive elderly subjects
DEPRESSIONE, ANZIANI E PSICOTERAPIA
VALUTAZIONE DELLE ALTERAZIONI COMPORTAMENTALI IN PAZIENTI CON DEMENZA DI ALZHEIMER
L’IPOTIROIDISMO NELLE PERSONE ANZIANE: IMPORTANZA DI UNA ADEGUATA TERAPIA SOSTITUTIVA ORMONALE
La prevalenza dei disturbi della ghiandola tiroidea aumenta con l’età, soprattutto nelle donne. L’ipofunzione tiroidea conclamata in età avanzata può manifestarsi clinicamente con sintomi e segni simili alle modificazioni che normalmente accompagnano l’invecchiamento o come disturbi di altri organi. Per tale motivo, un alto indice di sospetto è essenziale per rilevare l’ipotiroidismo in anziani con comorbilità multiple, alterazioni nutrizionali e/o polifarmacoterapia. La decisione di iniziare una terapia sostitutiva ormonale nell’ipotiroidismo conclamato non è discutibile. Viceversa, esiste ancora controversia sulla decisione di trattare o non trattare l’ipotiroidismo subclinico; le raccoma…
NECESSITÀ DEL RICOVERO IN RSA IN ALCUNI PAZIENTI CON DEMENZA DI ALZHEIMER. CASO CLINICO
CORRELAZIONE TRA DEMENZA E DEPRESSIONE. Studio su 60 pazienti ambulatoriali
Magnesium homeostasis and aging.
Aging is very often associated with magnesium (Mg) deficit. Total plasma magnesium concentrations are remarkably constant in healthy subjects throughout life, while total body Mg and Mg in the intracellular compartment tend to decrease with age. Dietary Mg deficiencies are common in the elderly population. Other frequent causes of Mg deficits in the elderly include reduced Mg intestinal absorption, reduced Mg bone stores, and excess urinary loss. Secondary Mg deficit in aging may result from different conditions and diseases often observed in the elderly (i.e. insulin resistance and/or type 2 diabetes mellitus) and drugs (i.e. use of hypermagnesuric diuretics). Chronic Mg deficits have been…
Elevati livelli di omocisteina e ridotta forza muscolare in soggetti anziani
EFFETTO DEGLI ESTRATTI DI PAPAYA FERMENTATA SULLO STRESS OSSIDATIVO IN PAZIENTI CON MALATTIA DI ALZHEIMER
Brain tissue is particularly susceptible to oxidative damage, which has been associated with pathological findings of Alzheimer's disease (AD), such as amyloid plaques and protein fibrils. Oxidative stress alterations, including increased production of reactive oxygen metabolites, decline of antioxidant systems, and decreased efficiency in repairing molecules, have been linked to the development of AD. Postmortem studies on brain tissue from AD patients have shown several oxidative damage markers, such as increased lipid peroxidation, oxidative damage of proteins, glyco-oxidation, and reduction of antioxidant systems. We studied 40 patients referred to our Geriatric Unit (age 78,2 ± 1,1 yea…
DEFICIT COGNITIVO E DIABETE. STUDIO OSSERVAZIONALE
CHIRURGIA BARIATRICA COME CAUSA DI OSTEOMALACIA / OSTEOPOROSI E DISABILITÀ SEVERE. CASO CLINICO
Elevated homocysteine is associated with lower handgrip strength in elderly subjects
MAGNESIUM HOMEOSTASIS AND AGING
aGING IS VERY OFTEN ASSOCIATED WITH MAGNESIUM (mG) DEFICIT.tOTAL PLASMA MAGNESIUM CONCENTRATIONS ARE REMARKABLY CONSTANT IN HEALTHY SUBJECTS THROUGHOUT LIFE
MILD COGNITIVE IMPAIRMENT: LA ZONA GRIGIA
INTERVENTI SUL CAREGIVER DEL PAZIENTE CON DEMENZA
IPERTENSIONE ARTERIOSA E DETERIORAMENTO COGNITIVO
DISTURBI DEL SONNO IN SOGGETTI ANZIANI
Correlazione tra LLC-B e infezione da HCV nell'anziano
DEPRESSIONE E RISCHIO DI EVENTI CEREBROVASCOLARI ACUTI
EcocolorDoppler epiaortico e transmuralico nella diagnosi differenziale delle demenze
QUALITA’ DI VITA NEGLI ANZIANI: POSSIBILI INDICATORI
LEPTINA E BMI IN SOGGETTI ANZIANI DIABETICI E NON DIABETICI
PREVENZIONE DELLE MALATTIE NEURODEGENERATIVE NELL’ANZIANO
DECLINO COGNITIVO E CADASIL: CASO CLINICO
SEPSI IN SOGGETTI PORTATORI DI ELETTROCATETERE INTRACARDIACO.DESCRIZIONE DI DUE CASI CLINICI
DEPRESSIONE E DISTURBI COGNITIVI NELL’ANZIANO
Circulating magnesium levels and disability in elderly hospitalized subjects
DOMOTICA, UTENZA DEBOLE E ANZIANI
PSICOTERAPIA CON PAZIENTI GERIATRICI: IL GRUPPO TERAPEUTICO COME STRUMENTO DI CAMBIAMENTO IN QUADRO DI UMORE DEPRESSO
ALTERAZIONI NUTRIZIONALI DELL’ANZIANO
Sepsi in soggetti portatori di elettrocatetere intracardiaco. escrizione di due casi clinici
MALATTIA DI ALZHEIMER: PREDISPOSIZIONE, PREVENZIONE E TERAPIE FARMACOLOGICHE
CO-MORBILITA’ E DEPRESSIONE NELL’ANZIANO
L’ALIMENTAZIONE NEI PAZIENTI ISTITUZIONALIZZANTI AFFETTI DA DEMENZA TIPO ALZHEIMER
DOLORE E QUALITA' DELLA VITA.L'IMPORTANZA DELLA VMD
ELEVATED HOMOCYSTEINE IS ASSOCIATED WITH LOWER HANDGRIP STRENGTH IN ELDERLY PERSONS
USO DI IPOGLICEMIZZANTI ORALI SECRETAGOGHI E CADUTE IN PAZIENTI DIABETICI ANZIANI RICOVERATI IN UN REPARTO PER ACUTI
VALUTAZIONE MULTIDIMENSIONALE IN UN GRUPPO DI PAZIENTI ANZIANI IMMIGRATI
Magnesium and Alzheimer’s Disease
Environmental factors, including nutrition and metal elements, are implicated in the pathophysiology of Alzheimer’s disease (AD). Several in vitro and in vivo data indicate a role for magnesium (Mg) in many biological and clinical aspects of AD. Mg deficiency, aside from having a negative impact on the energy production pathways required by the mitochondria to generate adenosine triphosphate, also affects many biochemical mechanisms vital for neuronal properties and synaptic plasticity, including the response of N-methyl- d -aspartate receptors to excitatory amino acids, stability, and viscosity of the cell membrane. Mg also has an action as a mild calcium antagonist, and as an antioxidant …
INVECCHIAMENTO DELLA POPOLAZIONE NEL MAGHREB
SEPSI IN SOGGETTI PORTATORI DI ELETTROCATETERE INTRACARDIACO
MALATTIA DI ALZHEIMER: PREDISPOSIZONE, PREVENZIONE E TERAPIE FARMACOLOGICHE
COENZIMA Q E MALATTIA DI PARKINSON
Ambiente e anziano: la domotica come ausilio per disabili e anziani
TERAPIA ACUTA DEL DOLORE E CAPACITÀ FUNZIONALE IN PAZIENTI AMBULATORIALI
Age, homocysteine, and oxidative stress: Relation to hypertension and type 2 diabetes mellitus
Abstract OBJECTIVES: Hyperhomocysteinemia and oxidative stress are independent risk factors for cardiovascular events, which occur more frequently in old age. We evaluated these parameters in relation to age and the presence of hypertension and type 2 diabetes mellitus. METHODS: Two hundred eighty-two subjects (female/male: 142/140; 141 were >65 years and 141 were <65 years; mean age 73.9 +/- 6.6 years and 52.5 +/- 8.2 years, respectively) were randomly recruited from those attending our institution. Blood pressure, anthropometric parameters, oxidative stress parameters (reactive oxygen species [ROS] and malondialdehyde [MDA]), and homocysteine levels were evaluated in participants. RESULTS…
AZITHROMYCIN IN AN OLDER WOMAN WITH DIABETIC GASTROPARESIS
Diabetic neuropathy is a common chronic complication of diabetes and cause of significant morbidity and mortality, because it may involve the autonomous and peripheral nervous systems. Autonomic diabetic neuropathy is a challenging chronic complication of long-standing diabetes manifested with hypotension, syncope, gastroparesis, diarrhea, constipation, bladder dysfunction, sexual dysfunction, cardiac arrest, and/or sudden death. We present a case of diabetic gastroparesis in an older woman. The patient was an 83-year-old woman with a 40-year history of type 2 diabetes who was admitted with hypoglycemia, malnutrition, persistent vomiting, and obstinate constipation. After several unsuccessf…
MCI ED EVOLUZIONE IN DEMENZA
Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease.
Abstract. Magnesium deficiency is present in several chronic, age-related diseases, including cardiovascular, metabolic and neurodegenerative diseases. Alzheimer’s disease (AD) is the most common cause of dementia. The aim of the present study was to study magnesium homeostasis in patients with mild to moderate AD. One hundred and one elderly (≥65 years) patients were consecutively recruited (mean age: 73.4±0.8 years; M/F: 42/59). In all patients, a comprehensive geriatric assessment was performed including cognitive and functional status. Admission criteria for the AD group (diagnosed according to the DSM-IV and the NINCDS-ADRDA criteria) included: mild to moderate cognitive impairment (MM…
DEMENZA E DISTURBI DELL’ALIMENTAZIONE
Effetti collaterali della terapia farmacologica dell'ipertensione arteriosa nel soggetto anziano
ELEVATI LIVELLI DI OMOCISTEINA E RIDOTTA FORZA MUSCOLARE IN SOGGETTI ANZIANI
Magnesio e Invecchiamento
IL SOSTEGNO AI CAREGIVER DI MALATI DI DEMENZA E/O ALZHEIMER: UNA RISORSA PER IL TRATTAMENTO EFFICACE. ESPEIENZA DI UN GRUPPO DI “AUTO-AIUTO”
Circulating magnesium levels and disability in elderly hospitalizated subjects
NECESSITÀ DI UNA PERIODICA ASSISTENZA GERIATRICA DOMICILIARE. DESCRIZIONE DI UN CASO CLINICO
Rapporto tra omocisteinemia, stress ossidativo ed età
UN NUOVO INDICE PROGNOSTICO-TERAPEUTICO IN ONCOLOGIA GERIATRICA
DEPRESSIONE E DEMENZA: STUDIO NEUROPSICOLOGICO
DIFFICOLTÀ DI DIAGNOSI DELLA DEPRESSIONE NELL’ANZIANO
TUMORE GASTROINTESTINALE STROMALE INDIFFERENZIATO (GIST)E PREGRESSA BILLROTH II IN UN PAZIENTE ANZIANO: SOLO CAUSALITA'?
ANZIANI E DEPRESSIONE. COME RICONOSCERLA TEMPESTIVAMENTE
SINTOMI COGNITIVI E DEPRESSIVI IN SOGGETTI NON DEMENTI CON MALATTIA CEREBROVASCOLARE SOTTOCORTICALE
Physiology of the aging bone and mechanisms of action of bisphosphonates.
Fragility fractures, a major public health concern, are expected to further increase due to aging of the world populations because age remains a cardinal, independent determinant of fracture risk. With aging the balance between bone formation and resorption during the remodeling process becomes negative, with increased resorption and reduced formation. Bisphosphonates (BPs) are widely prescribed anti-resorptive agents that inhibit osteoclasts attachment to bone matrix and enhance osteoclast apoptosis. BPs can be divided into nitrogen-containing (N-BPs) and non-nitrogen-containing BPs (non-N-BPs). Both classes induce apoptosis but they evoke it differently. Several studies have examined the …
DEPRESSIONE, AUTOPERCEZIONE DELLA SALUTE E STATO FUNZIONALE NEL PAZIENTE ANZIANO: EUROPEAN STUDY ON ADULT WELL-BEING (ESAW)
PARKINSON E DEMENZA : VALUTAZIONE COMPARATIVA TRA INDICI NEUROPSICOLOGICI E NEURORADIOLOGICI
IL DISTURBO DA PANICO NEGLI ANZIANI
Terapia con ipoglicemizzanti orali secretagoghi in pazienti anziani diabetici ricoverati in acuto
ANEMIA NELL’ANZIANO: PREVALENZA IN UNA POPOLAZIONE DI SOGGETTI GERIATRICI OSPEDALIZZATI
Dominguez LJ, Galioto A.,Pineo A.,Ferlisi A.,Bellavia G.,Putignano E.,Costanza G.,Barbagallo M.
IDROCEFALO CRONICO NELL’ANZIANO: CASO CLINICO
Health care for older people in Italy: The U.L.I.S.S.E. Project (Un link informatico sui servizi sanitari esistenti per l'anziano - a computerized network on health care services for older people).
OBJECTIVES: The U.L.I.S.S.E. study is aimed at describing older patients who are cared for in hospitals, home care or nursing homes in Italy. DESIGN: The U.L.I.S.S.E. study is an observational multicenter prospective 1-year study. SETTING: Overall, 23 acute geriatric or internal medicine hospital units, 11 home care services and 31 nursing homes participated in the study. MEASUREMENTS: The patient's evaluation was performed using comprehensive geriatric assessment instruments, i.e. the interRAI Minimum Data Set, while data on service characteristics were recorded using ad-hoc designed questionnaires. RESULTS: The older subjects who are in need of acute and long term care in Italy have simil…
CORRELAZIONI TRA RISCHIO DI CADUTE E UTILIZZO DI NEUROLETTICI IN PAZIENTI ISTITUZIONALIZZANTI
Combination of intensive cognitive rehabilitation and donepezil therapy in Alzheimer's disease (AD).
Acetylcholinesterase inhibitors (AchEIs) are extensively used in Alzheimer's disease (AD) while reality orientation therapy (ROT) is a cognitive rehabilitation indicated for mentally deteriorated patients. We aimed to evaluate the efficacy of the combination of donepezil with an intensive ROT with active participation of the caregiver. Patients with AD (n=100, mean age 78.4±4.3 years) initiated treatment with donepezil, 5mg/day; 62 of them underwent a 3-week, daily ROT and physical reactivation training with the caregiver (Group A); 38 participants received only donepezil therapy (Group B). All subjects were tested for cognitive and functional abilities at baseline, at the end of the traini…
MAGNESIUM METABOLISM IN INSULIN RESISTANCE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS
Magnesium plays a key role in regulating insulin action, insulin-mediated glucose uptake, and vascular tone. Intracellular magnesium depletion may result in a defective tyrosine—kinase activity at the insulin receptor level, in a postreceptorial impairment in insulin action, and clinically in a worsening of insulin resistance. Intra- and extracellular alterations of magnesium metabolism have been identified in clinical states characterized by insulin resistance, such as metabolic syndrome, hypertension, altered glucose tolerance, type 2 diabetes, and aging. Several studies, from our and other’s groups, have confi rmed the clinical relevance of alterations of magnesium homeostasis in these c…
HOSPICE E TERMINALITÀ IN PAZIENTI CON DEMENZA
Cardiovascular risk factors in centenarians"
Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons. In order to explain this evidence, there is a growing number of hypothesis that consider a combination of genetic factors and lifestyle aspects to elucidate the exceptional longevity of centenarians, able to overcome the most frequent mortality cause, which is a cardiovascular event. It has been suggested that a role on this better cardiovascular risk profile may be played by the inc…
TUMORE GASTROINTESTINALE STROMALE INDIFFERENZIATO (GIST) E PREGRESSA BILLROTH II IN UN PAZIENTE ANZIANO: SOLO CASUALITÀ?
TERAPIE DI RIABILITAZIONE COGNITIVA NEL COMPLESSO PARKINSON-DEMENZA NELL’ANZIANO. Caso clinico
DELIRIUM DURANTE LA DEGENZA OSPEDALIERA IN UN REPARTO GERIATRICO
EFFECTS OF POLYENOIC OMEGA-3 FATTY ACIDS ON OXIDATIVE STRESS IN HYPERTENSIVE ELDERLY SUBJECTS
MIGRATION, CARDIOVASCULAR RISK AND BLOOD PRESSURE MODIFICATIONS
LA DEPRESSIONE NELL’ANZIANO. NOSTRO STUDIO SU 100 SOGGETTI
RELAZIONE TRA M. DI PARKINSON E DEMENZA DI ALZHEIMER. CASO CLINICO
DISTURBI D’ANSIA NELL’ANZIANO
IL DOLORE NELLA DEMENZA. STUDIO SU 100 PAZIENTI
DELIRIUM, ANZIANI E OSPEDALE
IL RANK LIGANDO QUALE TARGET TERAPEUTICO NEL TRATTAMENTO DELLE PAZIENTI ANZIANE CON OSTEOPOROSI
Cortical and trabecular bone undergo a continuous and balanced remodeling process, which consists of a phase of resorption, mediated by osteoclasts, and a phase of neoformation mediated by osteoblasts. The activity of both, osteoblasts and osteoclasts, is regulated by the osteocytes, which are the most abundant cells in bone tissue. An imbalance of this process with an excessive resorption activity causes a loss of bone mass and microarchitectural deterioration of the skeleton, with consequent reduction of bone strength and increased risk of fractures. The ligand for the “Receptor Activator of Nuclear Factor Kappa- B” (RANK-L), a protein expressed by osteoblasts, plays a fundamental role in…
OSTEOPOROSI MASCHILE: UN CASO DI PARAPARESI CONSEGUENTE A MIELOPATIA DORSALE DA FRATTURA VERTEBRALE SEVERA
M.P.S. e M.C.I. segni e sintomi
Serum ionized magnesium in diabetic older persons
Objective. Several alterations of magnesium metabolism have been associated with type 2 diabetes pathophysiology, a condition particularly frequent in older persons. We aimed to evaluate serum total (Mg-tot) and serum ionized magnesium (Mg-ion) in older persons with type 2 diabetes in order to explore clinically applicable methods for the detection of magnesium deficit. Material/Methods: Mg-tot and Mg-ion were measured in 105 fasting subjects with type 2 diabetes (mean age: 71.10.8 years; M/F: 45/60) and in 100 age-matched non-diabetic control persons (mean age: 72.20.8 years; M/F: 42/58). Results: Mg-ion concentrations were significantly lower in diabetic persons compared with controls (…