0000000000909156

AUTHOR

Li Volti G.

The role of heme oxygenase and Hsp70 in trauma

The so called Heat-shock proteins (Hsp) are the product of different genes induced by a sudden and/or short-lasting temperature elevation. However, the term Hsp is generally used with great flexibility to indicate proteins induced also by other stressors besides heat shock. Many Hsp are also chaperones since they assist nascent polypeptides to fold correctly. Other canonical functions of chaperones include, in addition to protein folding, assisting protein refolding and translocation through membranes, ushering proteins damaged beyond repair to degradation, and dissolution of protein aggregates. Hsp play a key role in various human chronic diseases such as cancer, neurodegenerative diseases…

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Role of heme oxygenase-1 (HSP32) and HSP90 in glioblastoma

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The current treatment regimes for glioblastoma demonstrated a low efficiency and offer a poor prognosis. Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. The heat shockproteins, heme oxygenase-1 (HO-1) and Hsp90, serve these pivotal roles in tumor cells and have been identified as effective targets for developing therapeutics. This topic review summarizes the current preclinical and clinical evidences and rationale to define the potential of HO-1 and Hsp90 in GBM progression and chemoresistance.

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Effects of liraglutide on plasma ghrelin concentrations and oxidative stress in patients with type 2 diabetes: a 2-month prospective pilot study.

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