0000000000909705

AUTHOR

Siddhartha Paul

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Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair

2020

Neurodegeneration is a hallmark of many diseases and disorders of the central nervous system (CNS). High levels of neuroinflammation are often associated with irreparable damage to CNS cells due to the dysregulation of signaling cascades that are unable to restore a homeostatic balance. Due to the inherent complexity of the CNS, development of CNS-related therapeutics has met limited success. While stem cell therapy has been evaluated in the context of CNS repair, the mechanisms responsible for their functional properties have not been clearly defined. In recent years, there has been growing interest in the use of stem cell extracellular vesicles (EVs) for the treatment of various CNS patho…

0301 basic medicineinduced pluripotent stem cellsmedicine.medical_treatmentContext (language use)ReviewexosomesBiologyNeuroprotectionCell and Developmental Biology03 medical and health sciences0302 clinical medicinemedicineInduced pluripotent stem celllcsh:QH301-705.5Neuroinflammationmesenchymal stem cellsMesenchymal stem cellCell BiologyStem-cell therapycentral nervous systemMicrovesicles030104 developmental biologylcsh:Biology (General)030220 oncology & carcinogenesisStem cellextracellular vesiclesNeuroscienceDevelopmental BiologyFrontiers in Cell and Developmental Biology
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