0000000000918133
AUTHOR
M. Tumbarello
SUBOXONE EFFICACY IN TREATING DRUG ADDICTION: COMPARISON WITH METHADONE AND MONITORING OF PATIENTS IN THERAPY AT SERT OF MARSALA
Drug dependence and abuse is a public health problem as revealed by reports of state police that account overdoserelated deaths for 305 during 2015. Most of the dead were caused by heroin. Despite evidence that methadone maintenance treatment is effective, it remains a controversial therapy because of its indefinite provision of a dependence-producing medication. The aim of this work is to evaluate clinically the effectiveness of Suboxone in maintaining abstinence and preventing relapse. Suboxone consists of buprenorphine and naloxone in the 4:1 ratio. The former is a partial agonist on the receptor and its absorption is rapid, while Naloxone is an antagonist on the receptor k and it is abs…
Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing
Abstract Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46…
Epidemiology and Microbiology of Skin and Soft Tissue Infections: Preliminary Results of a National Registry
Skin and soft tissue infections (SSTIs) represent a wide range of clinical conditions characterized by a considerable variety of clinical presentations and severity. Their aetiology can also vary, with numerous possible causative pathogens. While other authors previously published analyses on several types of SSTI and on restricted types of patients, we conducted a large nationwide surveillance programme on behalf of the Italian Society of Infectious and Tropical Diseases to assess the clinical and microbiological characteristics of the whole SSTI spectrum, from mild to severe life-threatening infections, in both inpatients and outpatients. Twenty-five Infectious Diseases (ID) Centres throu…