0000000000918253
AUTHOR
Fabienne Clauw
showing 2 related works from this author
Mitochondrial basis of the anti-arrhythmic action of lidocaine and modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids
2012
The aim of this study was to evaluate the involvement of mitochondria in the mechanism of the anti-arrhythmic lidocaine. Rats were fed with a diet containing either n-6 polyunsaturated fatty acids (PUFAs, SSO group) or an equimolecular mixture of n-3 and n-6 PUFAs (FO group) for 8 weeks. The hearts were perfused according to the working mode using a medium with or without lidocaine 5 μM. They were then subjected to local ischemia (20 min) and reperfusion (30 min). Dietary n-3 PUFAs triggered the expected decrease in the n-6/n-3 PUFA ratio of cardiac phospholipids. Reperfusing the ischemic area favored the incidence of severe arrhythmias. Lidocaine treatment abolished almost completely reper…
Modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids of the anti-arrhythmic effects of lidocaine
2013
Comunication orale : Demaison L.Comunication orale : Demaison L.; Background: Enrichment of cardiac phospholipids with eicosapentaenoic acid (EPA) is known to be cardioprotective during ischemia/reperfusion. This study aimed at studying the effect of dietary EPA-rich fish oil on the occurrence of severe reperfusion arrhythmias, at determining if the anti-arrhythmic lidocaine modulates that effect and at trying to evaluate the mechanism of these treatments. Materials and Methods: Rats were fed two diets differing in their PUFA composition for 8 weeks. The first one contained 10% of sunflower seed oil (SSO) and the second one 5% of fish oil (FO) plus 5% of SSO. The hearts were then perfused a…