0000000000919683

AUTHOR

Dagmar Prasa

showing 4 related works from this author

Angiotensin II antagonists - an assessment of their acute toxicity.

2013

In Germany, increasing prescription rates of angiotensin II antagonists resulted in rising enquiries to Poisons Information Centres (PICs) during the last decade. Therefore, we aimed to assess their acute toxicity for deriving triage recommendations.An observational case series with data collected retrospectively from eight PICs in Austria, Germany and Switzerland. Inclusion criteria were monoexposure, defined dose, and documented follow-up.In total, 206 cases of exposures to angiotensin II antagonists were included (candesartan, 94; eprosartan, 3; irbesartan, 20; losartan, 26; olmesartan, 16; telmisartan, 18; and valsartan, 29). The median dose expressed as a multiple of their maximum dail…

AdultMalemedicine.medical_specialtyPoison Control CentersTime FactorsPharmacologyToxicologyIrbesartanInternal medicineGermanymedicineHumansAntihypertensive AgentsRetrospective Studiesbusiness.industryPoisoningEprosartanGeneral MedicineMiddle AgedAngiotensin IILosartanValsartanChild PreschoolMedian bodyFemaleTelmisartanDrug OverdoseHypotensionbusinessOlmesartanAngiotensin II Type 1 Receptor Blockersmedicine.drugClinical toxicology (Philadelphia, Pa.)
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MAGAM II – prospective observational multicentre poisons centres study on eye exposures caused by cleaning products

2019

Objective: Local effects on the eye following cleaning product exposures are frequently reported. According to EU chemicals legislation many cleaning products are labelled with Hazard Phrase 318 in...

AdultMalePoison Control CentersTime FactorsAdolescentgenetic structuresInjury controlAccident preventionDetergentsPoison controlToxicologyYoung Adult03 medical and health sciencesEye InjuriesInjury Severity Score0302 clinical medicineGermanyEnvironmental healthHumansMedicineProspective Studies030212 general & internal medicineChemical eye injuryChildAgedAged 80 and overbusiness.industryAge FactorsInfant030208 emergency & critical care medicineGeneral MedicineMiddle AgedCleaning product3. Good healthChild PreschoolFemaleObservational studybusinessProduct identificationClinical Toxicology
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Escitalopram causes fewer seizures in human overdose than citalopram

2010

Seizures are a recognized complication of acute overdose with the racemic (1:1 ratio of R- and S-enantiomers) selective serotonin reuptake inhibitor antidepressant citalopram.We tested the hypothesis that escitalopram (the therapeutically active S-enantiomer of citalopram) causes fewer seizures in overdose than citalopram at comparable doses of the S-enantiomer.Multicenter retrospective review of cases with citalopram and escitalopram overdose reported to German, Austrian, and Swiss Poisons Centers between 1997 and 2006.316 citalopram and 63 escitalopram cases were analyzed. Somnolence, nausea, vomiting, tachycardia, QT prolongation, and tremor occurred with similar frequency in both groups…

AdultMalePoison Control CentersAdolescentNauseaSerotonin reuptake inhibitor610 Medicine & healthCitalopramCitalopramToxicologyDrug overdosebehavioral disciplines and activitiesQT intervalYoung AdultSeizuresGermanymental disordersmedicineHumansEscitalopramAgedRetrospective StudiesAged 80 and over3005 ToxicologyStereoisomerismGeneral MedicineMiddle Agedmedicine.disease10199 Clinic for Clinical Pharmacology and ToxicologyAustriaAnesthesiaVomitingAntidepressantFemaleDrug Overdosemedicine.symptomPsychologySelective Serotonin Reuptake InhibitorsSwitzerlandmedicine.drug
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MAGAM II – prospective observational multicentre poisons centres study on eye exposures caused by cleaning products

2019

Objective: Local effects on the eye following cleaning product exposures are frequently reported. According to EU chemicals legislation many cleaning products are labelled with Hazard Phrase 318 indicating risk of irreversible eye damage. The objectives of this study were to identify cleaning products with potential for irreversible eye damage by collecting human exposure data from poisons centres (PC), and to clarify to what degree exact product identification is possible during a PC telephone call. Methods: MAGAM II was a multicentre binational prospective observational PC study. All human eye exposures to detergents or maintenance products reported to nine PCs taking calls from the publi…

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