0000000000920350

AUTHOR

R. Stefano

showing 3 related works from this author

Activity and toxicity of oxaliplatin plus raltitrexed in 5-fluorouracil refractory metastatic colorectal adeno-carcinoma

2004

Background: This study evaluated the antitumor efficacy and safety of a novel oxaliplatin/raltitrexed combination in pretreated advanced colorectal cancer patients. Patients and Methods: Forty-five patients with 5-fluorouracil-refractory metastatic colorectal cancer received raltitrexed 3.0 mg/m2 as a 15-minute intravenous (i.v.) infusion, followed 45 min later by l-OHP 130mg/m2 iv as 2-h venous infusion on 1 day every 3 weeks. All patients had histologically proven metastatic colorectal cancer, age 18-75, measurable disease and normal baseline biological values. Most patients (60%) had >2 disease sites. All patients were assessed for safety and also for response according to an intent-to-t…

OxaliplatinRaltitrexedMetastaseColorectal cancer
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Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

2021

Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of…

Laparoscopic surgerySettore MED/18 - CHIRURGIA GENERALEmedicine.medical_treatmentlaparoscopyCOVID-19; Elective surgery; Emergency surgery; Laparoscopic surgery; SurveyOral HealthLaparoscopic surgerycross infection (MeSH)COVID-19; Elective surgery; Emergency surgery; Laparoscopic surgery; Survey.Surveys and QuestionnairesEpidemiologyPandemicInfection controlPractice Patterns Physicians'emergency surgeryLaparoscopySurveyhumansmedicine.diagnostic_testGeneral Commentarylaparoscopic surgeryinfection controlItalyEmergency surgeryphysicians'Original ArticleElective Surgical ProcedureHumanheating ventilation air conditioningmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)fallow periodelective surgical procedurespandemicsNOaerosol generating proceduresSurvey.COVID-19; elective surgery; emergency surgery; laparoscopic surgery; survey; COVID-19; elective surgical procedures; humans; infection control; Italy; laparoscopy; pandemics; practice patterns physicians'; SARS-CoV-2; surveys and questionnairesmedicinesurveyElective surgeryElective surgeryInfection ControlElective Surgical ProcedurePandemicbusiness.industrySARS-CoV-2General surgerySurvey; Laparoscopic surgery; COVID-19; Elective surgery; Emergency surgeryCOVID-19practice patternsSurgeryelective surgerysurveys and questionnairesLaparoscopySurgerybusiness
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High-density ZnO nanowires for cellular biointerfaces: a new role as myogenic differentiation switch

2019

The design of artificial platforms for expanding undifferentiated stem cells is of tremendous importance for regenerative medicine [1]. We have recently demonstrated that a ZnO nanowires (NWs) decorated glass support permits to obtain a differentiation switch during proliferation for mesoangioblasts (MABs)– i.e. multipotent progenitor cells which are remarkable candidates for the therapy of muscle diseases [2]. We have optimized the ZnO NWs synthesis on glass surfaces by numerical simulations and experimental systematic investigations, considering zinc speciation and supersaturation [3]. In particular, we demonstrated by numerical simulations that the ligand ethylenediamine, at the isoelect…

cellular differentiationstem cellMesangioblastZnOregenerative medicineSettore CHIM/02 - Chimica Fisica
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