0000000000920476

AUTHOR

Martina Musella

showing 2 related works from this author

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

2017

ObjectiveCancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies.DesignTo discover potential therapeutics to be clinically investigated as single agent, we performed a screening with a panel of FDA-approved or investigational drugs on primary CRC cells enriched for CSCs (CRC-SCs) isolated from 27 patients. Candidate predictive biomarkers of efficacy were identified by integrating genomic, reverse-phase protein mic…

0301 basic medicinep53DNA ReplicationCELL CYCLE CONTROLDNA damageColorectal cancerColonmedicine.medical_treatmentAntineoplastic AgentsBiologyBioinformaticsmedicine.disease_causeDNA DAMAGETargeted therapy03 medical and health sciencesCancer stem cellCell Line TumormedicineHumansCHEK11506DRUG DEVELOPMENTOligonucleotide Array Sequence AnalysisMutationCOLORECTAL CANCERSettore MED/06 - ONCOLOGIA MEDICAGastroenterologyCHEMOTHERAPYmedicine.diseaseImmunohistochemistryPrexasertib030104 developmental biologyPyrazinesCheckpoint Kinase 1MutationCancer researchNeoplastic Stem CellsPyrazolesStem cellTumor Suppressor Protein p53Colorectal NeoplasmsGut
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Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

2021

Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of…

Laparoscopic surgerySettore MED/18 - CHIRURGIA GENERALEmedicine.medical_treatmentlaparoscopyCOVID-19; Elective surgery; Emergency surgery; Laparoscopic surgery; SurveyOral HealthLaparoscopic surgerycross infection (MeSH)COVID-19; Elective surgery; Emergency surgery; Laparoscopic surgery; Survey.Surveys and QuestionnairesEpidemiologyPandemicInfection controlPractice Patterns Physicians'emergency surgeryLaparoscopySurveyhumansmedicine.diagnostic_testGeneral Commentarylaparoscopic surgeryinfection controlItalyEmergency surgeryphysicians'Original ArticleElective Surgical ProcedureHumanheating ventilation air conditioningmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)fallow periodelective surgical procedurespandemicsNOaerosol generating proceduresSurvey.COVID-19; elective surgery; emergency surgery; laparoscopic surgery; survey; COVID-19; elective surgical procedures; humans; infection control; Italy; laparoscopy; pandemics; practice patterns physicians'; SARS-CoV-2; surveys and questionnairesmedicinesurveyElective surgeryElective surgeryInfection ControlElective Surgical ProcedurePandemicbusiness.industrySARS-CoV-2General surgerySurvey; Laparoscopic surgery; COVID-19; Elective surgery; Emergency surgeryCOVID-19practice patternsSurgeryelective surgerysurveys and questionnairesLaparoscopySurgerybusiness
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