0000000000923624

AUTHOR

Andrei Alic

showing 2 related works from this author

mRNAStab—a web application for mRNA stability analysis

2013

Abstract Eukaryotic gene expression is regulated both at the transcription and the mRNA degradation levels. The implementation of functional genomics methods that allow the simultaneous measurement of transcription (TR) and degradation (DR) rates for thousands of mRNAs is a huge improvement in this field. One of the best established methods for mRNA stability determination is genomic run-on (GRO). It allows the measurement of DR, TR and mRNA levels during cell dynamic responses. Here, we offer a software package that provides improved algorithms for determination of mRNA stability during dynamic GRO experiments. Availability and implementation: The program mRNAStab is freely accessible at h…

Statistics and ProbabilityComputer scienceRNA StabilityCellComputational biologyBioinformaticsBiochemistryTranscription (biology)Gene expressionMRNA degradationmedicineHumansWeb applicationRNA MessengerMolecular BiologyInternetMessenger RNAbusiness.industryRNAGenomicsComputer Science ApplicationsComputational Mathematicsmedicine.anatomical_structureComputational Theory and MathematicsMrna levelbusinessFunctional genomicsAlgorithmsSoftwareBioinformatics
researchProduct

mRNAstab : a web application for mRNA stability analysis

2013

Eukaryotic gene expression is regulated both at the transcription and the mRNA degradation levels. The implementation of functional genomics methods that allow the simultaneous measurement of transcription (TR) and degradation (DR) rates for thousands of mRNAs is a huge improvement in this field. One of the best established methods for mRNA stability determination is genomic run-on (GRO). It allows the measurement of DR, TR and mRNA levels during cell dynamic responses. Here, we offer a software package that provides improved algorithms for determination of mRNA stability during dynamic GRO experiments.

GenòmicaExpressió genèticaRNA
researchProduct