0000000000924716

AUTHOR

R. De Giorgio

showing 3 related works from this author

Gender difference in drug use in hospitalized elderly patients.

2015

Purpose The aims of this study were to evaluate whether or not there are gender differences in drug use at hospital admission and prescription at discharge and to evaluate the effect of hospitalization on medication patterns in the elderly. Method In-patients aged > 65 years included in the REPOSI registry during a recruitment period of 3 years (2008-2010-2012) were analyzed in order to evaluate drug use at hospital admission and prescription at discharge according to gender. Results A total of 3473 patients, 52% women and 48% men, were considered. Polypharmacy (> 5 drugs) is more frequent in men both at hospital admission and discharge. At hospital discharge, the number of prescripti…

DrugMalePediatricsmedicine.medical_specialtySettore MED/09 - Medicina Internamedia_common.quotation_subjectSocio-culturaleDrug Prescriptionselderly gender polypharmacyElderlyAge groupsDrug PrescriptionHospital dischargeInternal MedicineMedicineHumansMedical prescriptionSex DistributionPrescribed drugsmedia_commonAgedElderly; Gender; Polypharmacy; Internal MedicinePolypharmacyAged 80 and overSex Characteristicsbusiness.industryGenderSex CharacteristicPatient DischargeHospitalizationHospital admissionPolypharmacyFemalebusinessSex characteristicsHumanEuropean journal of internal medicine
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Need for Deprescribing in Hospital Elderly Patients Discharged with a Limited Life Expectancy: The REPOSI Study

2019

<b><i>Objective:</i></b> Older people approaching the end of life are at a high risk for adverse drug reactions. Approaching the end of life should change the therapeutic aims, triggering a reduction in the number of drugs.<b><i></i></b>The main aim of this study is to describe the preventive and symptomatic drug treatments prescribed to patients discharged with a limited life expectancy from internal medicine and geriatric wards. The secondary aim was to describe the potentially severe drug-drug interactions (DDI). <b><i>Materials and Methods:</i></b> We analyzed Registry of Polytherapies Societa Italiana di Medicina I…

0301 basic medicineDrugMalemedicine.medical_specialtyDeprescriptions020205 medical informaticsDrug-Related Side Effects and Adverse Reactionsmedia_common.quotation_subjectElderly; End of life; Limited life expectancy; Polypharmacy; Symptomatic medications; Aged 80 and over; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Italy; Male; Polypharmacy; Deprescriptions; Life Expectancy; Patient DischargeSocio-culturale02 engineering and technology03 medical and health sciencesElderly · End of life · Limited life expectancy · Polypharmacy · Symptomatic medicationsPharmacotherapyDeprescriptionsLife ExpectancyElderlySymptomatic medications0202 electrical engineering electronic engineering information engineeringmedicine80 and overHumansLS4_4Medical prescriptionElderly; End of life; Limited life expectancy; Polypharmacy; Symptomatic medicationsmedia_commonAgedPolypharmacyAged 80 and overOriginal Paperbusiness.industryGeneral MedicineElderly End-of-life Limited life expectancy Polypharmacy Preventing medications Symptomatic medicationsElderly End of life Limited life expectancy Polypharmacy Symptomatic medicationsPatient DischargeClonidineLimited life expectancyItalyEmergency medicineEnd of lifeLife expectancyPolypharmacyFemale030101 anatomy & morphologyDeprescribingbusinessmedicine.drugSymptomatic medication
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Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease.

2009

Patients with Parkinson’s disease develop motor disturbances often accompanied by peripheral autonomic dysfunctions, including gastrointestinal disorders, such as dysphagia, gastric stasis and constipation. While the mechanisms subserving enteric autonomic dysfunctions are not clearly understood, they may involve the enteric dopaminergic and/or nitrergic systems. In the present study, we demonstrate that rats with unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons develop a marked inhibition of propulsive activity compared to sham-operated controls, as indicated by a 60% reduction of daily fecal output at the 4th week of observation. Immunohistochemical data revealed …

Malemedicine.medical_specialtyParkinson's diseaseColonGastrointestinal DiseasesCONSTIPATIONENTERIC NEURONSIleumBiologyNitric OxideEnteric Nervous SystemNOLesionRats Sprague-Dawleychemistry.chemical_compoundParkinsonian DisordersIleumInternal medicineNitrergic NeuronsmedicineAnimalsOxidopamineGUT DYSFUNCTIONNeuronal PlasticityGeneral NeuroscienceDopaminergicParkinson Diseasemedicine.diseaseImmunohistochemistryRatsDisease Models Animalmedicine.anatomical_structureEndocrinologychemistryCONSTIPATION; ENTERIC NEURONS; GUT DYSFUNCTION; NEUROPLASTICITY; NITRIC OXIDEEnteric nervous systemNeuronmedicine.symptomConstipation Enteric neurons Gut dysfunction Neuroplasticity Nitric oxideGastrointestinal MotilityNitrergic NeuronNEUROPLASTICITYOxidopamineNeuroscience letters
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