Effect of HSP60 on fibrillogenesis of A-beta amyloid peptide

Alzheimer Hsp60 Aggregation

Radiation engineered functionalized nanogels as platform for biomedical nanocarriers

SELF-ASSEMBLY OF DEGALACTOSYLATED XYLOGLUCAN FROM TAMARIND SEEDS

Radiation sculpured nanogels as platform for novel therapeutic systems

Water-borne polymeric nanoparticles for glutathione-mediated intracellular delivery of anticancer drugs

A new family of water-borne, biocompatible and carboxyl- functionalized nanogels was developed for glutathione- mediated delivery of anticancer drugs. Poly(N-vinyl- pyrrolidone)-co-acrylic acid nanogels were generated by e- beam irradiation of aqueous solutions of a crosslinkable polymer, using industrial-type linear accelerators and set- ups. Nanogels physico-chemical properties and colloidal stability, in a wide pH range, were investigated. In vitro cell studies proved that the nanogels are fully biocompatible and able to quantitatively bypass cellular membrane. An anticancer drug, doxorubicin (DOX), was linked to the carboxyl groups of NGs through a spacer containing a disulphide cleavab…

Macromolecular engineering of hydrogels: from macro to nano scalar materials for different levels of biointeraction

Radiation engineered polymer nanocarriers for a new generation of nanoparticles based tumor specific radiopharmaceuticals

Studies of network organization and dynamics of e-beam crosslinked PVPs: From macro to nano

Abstract In this work the influence of poly(N-vinyl pyrrolidone) (PVP) concentration in water on the organization and dynamics of the corresponding macro-/nanogel networks has been systematically investigated. Irradiation has been performed at the same irradiation dose (within the sterilization dose range) and dose rate. In the selected irradiation conditions, the transition between macroscopic gelation and micro-/nanogels formation is observed just below the critical overlap concentration (∼1 wt%), whereas the net prevalence of intra-molecular over inter-molecular crosslinking occurs at a lower polymer concentration (below 0.25 wt%). Dynamic–mechanical spectroscopy has been applied as a cl…

Radiation Engineering of Xyloglucan Hydrogels

Xyloglucans (XGs) are interesting substrates for the production of scaffolds for tissue engineering, drug delivery depots and hydrogel dressings, thanks to their ability to gel in appropriate conditions, such as in the presence of hydro-alcoholic solvents or by addition of sugar molecules. Due to their natural source, they are characterized by high average molecular weights and broad molecular weight distributions. High energy irradiation is a suitable tool to reduce polysaccharides molecular weight without a dramatic alteration of the polymer chemical structure and gelation ability. In this work, the effect of the radiation dose on the molecular weight of a XG derived from Tamarind seeds i…

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