Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease
As acute pancreatitis progresses to the severe form, a life-threatening systemic inflammation is triggered. Although the mechanisms involved in this process are not yet well understood, it has been proposed that circulating exosomes may be involved in the progression of inflammation from the pancreas to distant organs. Here, the inflammatory capacity and protein profile of plasma exosomes obtained during the first 24 h of hospitalization of patients diagnosed with acute pancreatitis were characterized and compared with the final severity of the disease. We found that the final severity of the disease strongly correlates with the inflammatory capacity of exosomes in the early stages of acute…
Surfing transcriptomic landscapes. A step beyond the annotation of chromosome 16 proteome
All participating laboratories are members of ProteoRed-ISCIII.-- et al.
General Statistical Framework for Quantitative Proteomics by Stable Isotope Labeling
Pedro J. Navarro et al.
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
6 p.-2 fig.-2 tab.