Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke.

Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B(12) (B(12) change during ischemic stroke as accompaniment of the tissue damage. The relationship between these changes remains scantly investigated. We evaluated the variation of these molecules in the 48 h after acute large artery atherothrombotic stroke (LAAS) and searched for the presence of matched variation of them. The study involved 50 subjects affected by acute LAAS and 49 healthy controls. Plasma levels of tHcy and Cys were significantly higher and serum levels of FA and B(12) and plasma levels of rGSH were significantly lower in the patients than…

Levetiracetam in the treatment of vascular chorea: a case report

Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study.

Background: In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings remain uncertain. Methods: This prospective multicenter observational study aimed to estimate the rates of ischemic and bleeding events and their determinants in the follow-up of consecutive patients with atrial fibrillation who suffered an acute cerebrovascular ischemic event while on nonvitamin K antagonist oral anticoagulant treatment. Afterwards, we compared the estimated risks of ischemic and bleeding events between the patients in whom anticoagulant therapy was chan…

Thunderclap Headache and Reversible posterior Leukoencephalopathy: Case Report

Effects of cerebellar TMS on motor cortex of patients with focal dystonia

Frequency and determinants for hemorragic transformation of cerebral infarction

LOW-DOSAGE TOPIRAMATE IN PROPHYLAXIS OF MIGRAINE: RESULTS OF A RETROSPECTIVE STUDY IN 490 PATIENTS.

FREQUENCY AND DETETRIMINANTS OF HEMORRHAGIC TRASFORMATION OF CEREBRAL INFARCTION

Idiopathic Parkinson’s Disease and Associated Conditions: Results From a Case-Control Study

Ruolo dell'area prefrontale dorsolaterale sinistra nel controllo della nocicezione e dei meccanismi di sensibilizzazione: effetti della

Reduced Admissions for Cerebrovascular Events during COVID-19 Outbreak in Italy

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CEREBELLUM AND TIME PERCEPTION: A LOW-FREQUENCY STIMULATION STUDY IN HEALTHY SUBJECTS

Frequency and determinants for hemorrhagic trasformation of cerebral infarction

GENOTYPIC AND PHENOTIPIC FACTORS IN ISCHEMIC STROKE IN YOUNG ADULTS

Disturbi dell'articolazione temporo-mandibolare e alterazioni motorie-sensoriali dell'apparato oculare

Ruolo dell'area prefrontale dorsolaterale sinistra nel controllo della nocicezione e dei meccanismi di sensibilizzazione: effetti della stimolazione magnetica transcranica ripetitiva su un modello di dolore neuropatico indotto da capsaicina in soggetti normali

Effects of 7-OH-DPAT, a D3 receptor agonist, on pain modulation, in the rat

Frequency and Determinants for Hemorrhagic Transformation of Cerebral Infarction

Risk Factors for Intracerebral Hemorrhage in Patients With Atrial Fibrillation on Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention

Background and Purpose: Clinical trials on stroke prevention in patients with atrial fibrillation have consistently shown clinical benefit from either warfarin or non–vitamin K antagonist oral anticoagulants (NOACs). NOAC-treated patients have consistently reported to be at lower risk for intracerebral hemorrhage (ICH) than warfarin-treated patients. The aims of this prospective, multicenter, multinational, unmatched, case-control study were (1) to investigate for risk factors that could predict ICH occurring in patients with atrial fibrillation during NOAC treatment and (2) to evaluate the role of CHA 2 DS 2 -VASc and HAS-BLED scores in the same setting. Methods: Cases were consecutive pa…

Effetti indotti dal PD 128907, potente agonista D3, sulla sequenza di sazietà, nel ratto.

The fixed behavioral sequence exhibited by rat in response to food ingestion is called behavioral satiety sequence (BSS): cessation of feeding is followed by a period of grooming and activity endings with a period of resting. This profile of BSS is closely linked to satiety. In different experimental design, BSS has been used to investigate whether reduction of food intake, induced by different drugs like D1 and D2 receptor agonist, was determined by an influence on processes underlying satiety or on specific behaviors associated to feeding. Our recent data have shown that PD 128907, a D3 receptor agonist, produced a decrease of food intake. In order to assess the mechanism involved in D3 r…

Genotypic and phenotypic factors in ischemic stroke in young adults

Headache in cerebrospinal fluid volume depletion syndrome: A case report

Cerebrospinal fluid (CSF) volume depletion syndrome is due to leakage of cerebrospinal fluid through lesions of the dural sac at the level of the cranial base or of the spine. When past medical history is negative for recent trauma or surgery, the term spontaneous intracranial hypotension (SIH) is used. SIH is characterized clinically by orthostatic headache, neck pain, nausea, emesis, horizontal diplopia, tinnitus, plugged ear, hearing difficulties, blurring of vision, facial numbness, and upper limb radicular symptoms. In SIH, brain and cervical MR scans show a diffuse pachymeningeal gadolinium enhancement that ends at the site of CSF leakage. The application of epidural blood patches has…

Frequency and determinants for hemorrhagic transformation of cerebral infarction.

<i>Background:</i> Frequency and associated risk factors for hemorrhagic transformation (HT), a worrying complication of ischemic stroke (IS), are not clearly defined. Our aim was to estimate the overall frequency and risk factors for HT in a hospital-based population. <i>Methods:</i> A retrospective review of medical records of patients discharged from our department during the period 2004–2006 with a diagnosis of anterior IS. Demographic, clinical and hematological information was collected. Uni- and multivariate logistic regression analyses were used to estimate risk for spontaneous HT. <i>Results:</i> We included 240 patients (125 males, 52%), mean ag…

EFFECTS OF LEFT DLPFC RTMS ON PAIN INDUCED BY CAPSAICIN IN HEALTHY SUBJECT.

Effetti della modulazione cerebellare sulla corteccia motoria di pazienti con distonie focali

Design Criteria and Experimental Tests of a PM Linear Electrical Generator for the Exploitation of Sea Waves Energy

Progressive stroke in pontine infarction

Objective –  The pathogenesis of isolated pontine infarctions is still unclear, being attributed both to small or large vessel disease. The extension of infarcted tissue to the pons surface has been indicated as a possible marker of basilar branch atheromatous disease and some neuroimaging evidence confirms this finding. Methods –  On the basis of Kim’s et al., study, we performed a revision of the literature addressing this topic. Results –  Several authors confirm an association between basilar artery branch disease and isolated pontine infarction; moreover, the enlargement of pontine lesion seems to be associated with neurological worsening. We therefore performed a brief analysis of pos…

Effects of cerebellar TMS on motor cortex of patient with focal dystonia: a preliminary report

Recent evidence suggests a role for cerebellum in pathophysiology of dystonia. Here we explored, the cerebellar modulation of motor cortex in patients with focal upper limb dystonia. Eight patients and eight controls underwent a transcranial magnetic stimulation protocol to study the cerebellar-brain-inhibition (CBI): a conditioning cerebellar stimulus (CCS) was followed 5 ms after by the contralateral motor cortex stimulation (test stimulus: TS). We explored the effects of CBI on MEP amplitude, short intracortical inhibition (SICI) and intracortical facilitation (ICF) measures. At baseline no differences in TS-MEP amplitude, SICI or ICF were found between patients and controls. Cerebellar-…

Prophylaxis of hemicrania continua with topiramate: report of two cases.