0000000000928348
AUTHOR
A. Di Cristina
In vivo liver expression of TLR2, TLR3 and TLR7 in chronic hepatitis C
The role of innate immune response mediated by Toll-like receptors in HCV infection, is not yet well understood and there is a lack of data regarding liver tissue expression of these molecules in chronic hepatitis C (CHC). Our study is aimed to investigate ex vivo, liver expression of TLR2, TLR3 and TLR7, which are more involved in the immune-pathogenesis of CHC, and to explore possible correlations with features of disease. We obtained liver biopsies and collected peripheral blood mononuclear cells (PBMC) from 23 consecutive patients with CHC and from 6 patients of control, without liver disease, undergoing surgery for cholecystectomy. The levels of TLRs mRNA in the samples were determined…
CCDC 644638: Experimental Crystal Structure Determination
Related Article: D.Raffa, B.Maggio, S.Cascioferro, M.V.Raimondi, D.Schillaci, G.Gallo, G.Daidone, S.Plescia, F.Meneghetti, G.Bombieri, A.Di Cristina, R.M.Pipitone, S.Grimaudo, M.Tolomeo|2009|Eur.J.Med.Chem.|44|165|doi:10.1016/j.ejmech.2008.03.023