0000000000928933
AUTHOR
Alain Grynberg
showing 8 related works from this author
Dietary n-3 PUFAs affect the blood pressure rise and the cardiac function modulation in a hyperinsulinemia rat model in vivo
2004
National audience; This study was designed to assess in vivo the cardiovascular consequences of a dietary docosahexaenoic (DHA) or eicosapentaenoic (EPA) acid specific intake in a hyperinsulinemia (HI) model presented by fructose-induced insulin-resistant rats. Wistar rat (n=6 in each dietary group of control or HI rats) were fed for two months a diet containing 62% fructose, and supplemented (or not for control, NFD) with either DHA or EPA (240 mg per day). Modifications of the cardiovascular parameters (rise in blood pressure (BP), heart rate (HR), modulation, ECG) were continously monitored using an intra-abdominal implanted telemetry system in HI rats. The myocardial phospolipid fatty a…
Evaluation des effets d’un apport alimentaire en acides α-linolénique ou docosahexaénoïque sur les profils en acides gras des membranes et leurs cons…
2005
National audience
Oxygen and substrate deprivation on isolated rat cardiac myocytes : temporal relationship between electromechanical and biochemical consequences
1990
The effects of hypoxia and reoxygenation on action potentials (AP), contractions, and certain biochemical parameters were studied in isolated rat ventricular myocytes in monolayer culture in the presence and absence of glucose. Substrate deprivation alone had no influence on the basal properties. In the presence of glucose, a 4-h hypoxic treatment caused only a moderate decrease in AP amplitude and rate. In substrate-free conditions, hypoxia induced a gradual decline in plateau potential level and in AP duration and rate, followed by rhythm abnormalities and a failure of the electromechanical coupling. Spontaneous AP generation then ceased, and the resting potential decreased with increase…
Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in …
2009
International audience; This study was designed to evaluate the effects of individual dietary long-chain n-3 polyunsaturated fatty acids (LCPUFA) on hypertension and cardiac consecutive disorders in spontaneously hypertensive rats (SHR) as compared to Wistar-Kyoto rats (WKY). Rats were fed for 2 months an eicosapentaenoic (EPA)- or docosahexaenoic acid (DHA)-rich diet (240 mg/day) or an n-3 PUFA-free diet. Male SHR (n=6), implanted with cardiovascular telemetry devices, were housed in individual cages for continuous measurements of cardiovascular parameters (blood pressure (BP) and heart rate (HR)) during either activity or rest periods, ECG were recorded during the quiet period. The n-6 PU…
Effet à long terme d’un apport alimentaire en acides α-linolénique ou docosahexaénoïque sur l’incorporation membranaire du DHA et ses conséquences ca…
2004
National audience
Influence du DHA alimentaire sur les fonctions cardiovasculaires chez le rat SHR in vivo
2003
National audience
Long term effect of dietary alpha-linolenic (ALA) or docosahexaenoic acid (DHA) on the incorporation of of DHA and its influence in vivo on the rat h…
2005
National audience; The present study was designed to evaluate if a high (20% of the fatty acids) and long term supply of dietary ALA as supplied in the diet by whole grain extruded linseed (Valorex) can increase the endogenous pro- duction of the long-chain n-3 PUFAs in healthy adult rats, and influence heart rate and adrenergic response like a DHA-rich diet. The enrichment in DHA was evaluated using fatty acid analysis by GC in various membranes (heart, brain, .. .) after 2, 4, 6 and 8 months of feeding (n = 7) from male Wistar rats randomly assigned to three groups (n = 36) and fed a normal fat diet (NFD), a ALA-rich diet (ALA) or a DHA-rich diet (DHA). In parallel three groups (n = 8) we…
Influence du DHA alimentaire sur la fonction cardiovasculaire chez le rat SHR in vivo
2004
National audience