0000000000932131

AUTHOR

Pedro Mondejar-lopez

showing 3 related works from this author

Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children.

2019

Tracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. Our working hypothesis was that TRB could trigger by itself recurrent or persistent respiratory symptoms. The objective of this retrospective and multicentre study of children with a diagnosis of TRB, coming from the main paediatric pulmonology units of Spain, was to determine the anatomical and clinical characteristics, including comorbidities, of TRB in childhood and their im…

Pulmonary and Respiratory MedicineMaleDown syndromePediatricsmedicine.medical_specialtyAdolescentCardiovascular AbnormalitiesBronchi03 medical and health sciences0302 clinical medicineBronchoscopy030225 pediatricsBronchoscopymedicinePrevalenceHumansRespiratory systemBronchitisChildPathologicalTracheal Diseasesmedicine.diagnostic_testbusiness.industryRefluxInfantPneumoniamedicine.diseasePathogenicityTrachea030228 respiratory systemTracheomalaciaSpainTracheal bronchusChild PreschoolPediatrics Perinatology and Child HealthGastroesophageal RefluxFemaleDown SyndromebusinessPediatric pulmonology
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Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey

2020

CF-COVID19-Spain Registry Group.

AdultMalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyPneumonia ViralPopulationDiseaseRisk AssessmentCystic fibrosisArticleCystic fibrosisBetacoronavirus03 medical and health sciencesCOVID-19 Testing0302 clinical medicinemedicineHumansRegistries030212 general & internal medicineMortalityeducationPandemicsRetrospective Studieseducation.field_of_studyClinical Laboratory Techniquesbusiness.industrySARS-CoV-2IncidenceIncidence (epidemiology)Mortality rateCOVID-19Retrospective cohort studymedicine.diseaseCoronavirus030228 respiratory systemSpainFemaleObservational studyCoronavirus InfectionsRisk assessmentbusiness
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Cystic fibrosis treatment: targeting the basic defect

2017

ABSTRACTIntroduction: Cystic Fibrosis (CF) is a disease caused by different class mutations in the CF transmembrane conductance regulator (CFTR) gene. It can therefore benefit from a personalized medicine approach based on the individual genotype of each patient.Areas covered: This review provides a detailed overview of the current major development of new CF treatments that target the basic CF defect. The review summarizes gene therapy, mRNA repair strategies, read-through agents, and CFTR-modulators (potentiators, correctors, stabilizers, amplifiers and different combination therapies).Expert opinion: We are currently perhaps at the most exciting stage in the history of CF, with the poten…

0301 basic medicinePathologymedicine.medical_specialtyMutationCombination therapybusiness.industryHealth PolicyGenetic enhancementDiseasePotentiatorBioinformaticsmedicine.diseasemedicine.disease_causeCystic fibrosisIvacaftor03 medical and health sciences030104 developmental biology0302 clinical medicine030228 respiratory systemMedicinePharmacology (medical)Personalized medicinebusinessPharmacology Toxicology and Pharmaceutics (miscellaneous)medicine.drugExpert Opinion on Orphan Drugs
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