turbinate surgery by radiofrequency for sleep-disordered breathing

Far infrared radiofrequency generated a new non invasive method for the treatment of head and neck pathologies

Uvulopalatoplasty by radiosurgery

Valutazione della funzione neuroautonomica nella Malattia di Ménière

Eppure,sembrava una neoplasia...Anomala localizzazione laringea di tiroide ectopica

Radiosurgery in the treatment of the glottic plane carcinoma

Abstract During the last 20 years, various conservative surgical techniques have been proposed to treat larynx cancer. On the basis of our various experiences and of the ultrastructural data on the tissues treated with radiowaves, we decided to also use radiosurgery in operations under direct microlaryngoscopy. We select 18 patients suffering from epidermoid carcinoma. These patients had been referred to our ENT clinic at the Polichnico of Palermo between 1999 and 2001. The authors describe the surgical procedures used and emphasize the advantages of radiosurgery in the treatment of larynx cancer.

The prognostic role of TP53 mutations in advanced laryngeal squamous cell carcinoma (LSCC).

Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma

The p16INK4a gene, localized within chromosome 9p21, has been identified as a cyclin-dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series of 64 untreated patients (median of follow up 53 months) undergoing surgical resection for locally advanced laryngeal squamous-cell carcinomas (LSCCs) has been studied prospectively. Our purpose was to investigate p16 alterations (9p21 allelic loss, hypermethylation and point mutations) and their possible association with clinico-pathological data and flow cytometric variables (DNA-ploidy and S-phase fraction (SPF)…

L'ELETTROMIOGRAFIA PREOPERATORIA DEI MUSCOLI NASALI

EPPURE SEMBRAVA UNA NEOPLASIA...ANOMALA LOCALIZZAZIONE DI TIROIDE ECTOPICA

LA RINOPLASTICA SECONDO FERNANDO ORTIZ-MONASTERIO: NOSTRA ESPERIENZA

Methotrexate, Vinblastine, Epidoxorubicin, and Bleomycin as Second-Line Chemotherapy for Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck

Thirty evaluable patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck region previously treated with cisplatin-based chemotherapy were treated with a combination of methotrexate, vinblastine, epidoxorubicin, and bleomycin as second-line chemotherapy. Besides surgery and/or radiotherapy all patients had previously received chemotherapy as induction therapy or as palliation for recurrent disease. Only 20% of patients achieved a partial objective response with a mean duration of 5.6 months (range 3.2-6.2), and 30% of patients had a stabilization of disease with a mean duration of 4.2+ months (range 3.8-6.0). Patients who responded had rhinopharyngeal carcinoma…

RUOLO DI P53 E DEI GENI K-RAS EDH-RAS NELLA TUMORIGENESI DELLE GHIANDOLE SALIVARI

Insuccessi anatomici e funzionali nella chirurgia dell’orecchio medio.

A pilot study of vinorelbine on a weekly schedule in recurrent and/or metastatic squamous cell carcinoma of the head and neck.

Vinorelbine (VNR), 5′-nor-anhydrovinblastine, is a new semi-synthetic vinka alkaloid with selective affinity for mitotic microtubules, which has been shown to be active against several non small cell lung cancer lines in vitro [1]. VNR has been reported to yield a 34.7 % and 20 % overall response rate in patients with squamous cell lung carcinoma and bronchial adenocarcinoma respectively [2]. Moreover, VNR has been shown to be active in advanced breast carcinoma where it may induce a 30–50 % response rate depending on the extent of pretreatment [3]. We tested the activity and toxicity of single agent VNR given on a weekly schedule in a series of patients with recurrent and/or metastatic squ…

Use of intraoperative video endoscopy during anterior inferior hyoid suspension surgery

UTILIZZO DELLE RADIOFREQUENZE NEL TRATTAMENTO CHIRURGICO DEL SIMPLE SNORING

Trattamento chirurgico endoscopico della paralisi ricorrenziale in adduzione

INSUCCESSI ANATOMICI NELLA CHIRUGIA DELL'ORECCHIO MEDIO

EFFETTI IMMUNOMODULANTI DEGLI ESTRATTI DI ECHINACEA ANGUSTIFOLIA E PURPUREA NEL TRATTAMENTO DELLE TONSILLITI CRONICHE IN ETA' PEDIATRICA

The Role of Vitamin C and Melatonin on Precancerosis of Oral Mucosa

Skin health restoration after craniofacial cancer resection. our exeperience with a new patented method

Weekly 5-fluorouracil and folinic acid plus escalating doses of cisplatin with glutathione protection in patients with advanced head and neck cancer.

Twenty-two patients with advanced head and neck carcinoma were treated with 5FU 400 mg-2 m-1 week and folinic acid 500 mg m-2 week-1 plus CDDP in escalating doses from 20 to 40 mg m-2 week-1 without forced diuresis. Reduced gluthatione at the dose of 1.5 g m-2 was employed to protect patients from CDDP-related nephrotoxicity. The aims of the study were: a) to evaluate the therapeutic efficacy of this schedule, and b) to evaluate reduced gluthatione as uroprotector. Out of 20 evaluable patients 14 (70 %) had a major objective response. A CR with a mean duration of 9.0+ months was achieved in 15 % of the patients, a PR of 5.8+ months in 55 % of the patients, while 3 patients had stable diseas…

BIOGENETIC FAR INFRARED SURGERY GENERATED BY NOVEL BIOCOMPATIBLE ALLOYMATERIAL

Bone Morphogenetic Protein-rhBMP2- In Aesthetic-Functional Maxillo-Facial Surgery After Oncological Resections: Case Report

COMBINING SEPTORHINOPLASTY AND F.E.S.S. WHY, WHEN AND HOW

TREATMENT OF FIBROUS HYPERPLASIA OF THE MAXILLARY TUBEROSITY AND PALATE WITH RADIO FREQUENCY AND FIBRIN GLUE: A CASE REPORT

Combinare F.E.S.S. e settorinoplastica. Perchè, quando e come

Schwannoma of the larynx. Case report

Neuretogenous tumours of the larynx are extremely uncommon. We present a case of schwannoma of the larynx and review pertinent data in the literature. Laryngeal schwannoma was discovered in a 80-year-old woman who complained of persistent dysphonia. The histological findings leading to diagnosis together with the therapeutic surgical procedure are described. There was no postoperative complication and functional outcome was excellent at six months follow-up, demonstrating that conservative surgery is required for this type of disease. Conservative surgery provides excellent results. Although very rare, schwannoma should be taken into consideration in the differential diagnosis of any laryng…

TP53, H-K-RAS, P16INK4A GENE MOLECULAR ANALYSIS IN SALIVARY GLAND TUMORS

Flow cytometric DNA analysis and lysosomal cathepsins b and l in locally advanced laryngeal cancer. Relationship with clinicopathologic parameters and prognostic significance

Background. The traditional factors of locally advanced laryngeal squamous cell carcinoma (LSCC) have limited predictive value for the identification of high risk patients. Therefore, it is extremely important to define prognostic factors that identify the more aggressive types. Reliable and reproducible prognostic indicators are being investigated to help clinicians identify high risk groups and address more rational treatment. Methods. Flow cytometric DNA ploidy and S-phase fraction (SPF) measurements were performed on frozen tumor tissues from a consecutive series of 71 patients with Stage III and IV LSCC. Lysosomal cathepsin B and L activity levels were determined biochemically in match…

Anestesia totalmente endovenosa nella chirurgia pediatrica otorinolaringoiatrica

RUOLO DI P53 E DEI GENI K-RAS ED H-RAS NELLA TUMORIGENESI DEI CARCINOMI DELLE GHIANDOLE SALIVARI

UTILIZZO DELLE RAADIOFREQUENZE NEL TRATTAMENTO CHIRURGICO DEL SIMPLE SNORING

Radiosurgery in the treatment of laryngeal abductor paralysis

Abstract Abductor true vocal cord paralysis is a complex condition that requires the surgeon to perform an emergency tracheotomy to eliminate the symptom of dyspnea. Throughout the past 20 years, corrective surgery has reverted to techniques using external or endoscopic techniques. For 5 years now, we have used high frequency radiosurgery by Ellman to treat various ENT conditions in our clinic. The experience we have gained has encouraged us to use this method in endoscopic surgery as well, in the treatment of laryngeal abductor paralysis under suspension microlaryngoscopy. Twelve patients were examined between 1999 and 2002. Diagnosis was performed through flexible fiberoptic videolaryngos…

Important Biomolecular Indicators In Locally Advanced Laryngeal Squamous Carcinoma: P16 Mutations

A Phase II Study of Levofolinic Acid and 5-Fluorouracil Plus Cisplatin in Patients with Advanced Head and Neck Squamous Cell Carcinoma

Forty patients with advanced squamous cell carcinoma of the head and neck (SCHNC) were treated with a combination of levofolinic acid 100 mg/m2+5-fluorouracil 375 mg/m2 in a 4-hour infusion plus cisplatin 20 mg/m2 in a 2-hour infusion for 5 consecutive days, repeated every 21-28 days. In the group of 20 previously untreated patients, a 90% overall response rate (ORR) with a 30% complete response rate (CRR) was obtained. In the group of 20 pretreated patients with recurrent and/or metastatic SCHNC, a 55% ORR with 15% CRR was achieved. This treatment was given on an outpatient basis and was generally very well tolerated with only 2 patients requiring hospitalization. Grade 1-2 gastrointestina…

TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma

ToprospectivelyevaluatetheprognosticsignificanceofTP53,H-,K-,andN-Rasmutations,DNA-ploidyandS-phasefraction(SPF) in patients affected by locally advanced laryngeal squamous cell carcinoma (LSCC). Eight-one patients (median follow-up was 71 months) who underwent resective surgery for primary operable locally advanced LSCC were analyzed. Tumor DNA was screened for mutational analysis by PCR/SSCP and sequencing. DNA-ploidy and SPF were performed byflow cytometric analyses. Thirty-six patients (44%) had, at least, a mutation in the TP53 gene. Of them, 22% (8/36) had double mutations and 3% (1/36) had triplemutations.Intotal,46TP53mutationswereobserved.Themajority(41%)oftheseoccurinexon5(19/46),…