0000000000934082

AUTHOR

P Lionetti

showing 6 related works from this author

I polimorfismi del gene IRGM sono associati al comportamento fistolizzante della malattia di Crohn.

2008

SNPMalattia di Crohn.
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1001 infusions of Infliximab in children with IBD: a 10 years study from the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition

2009

Infliximab Pediatric IBD
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Serological Screening of Celiac Disease: Choosing the best tests under two years.

2005

Aga CeliachiaSettore MED/38 - Pediatria Generale E SpecialisticaAga Serology
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Infliximab in children with inflammatory bowel disease in Italy: Efficacy.

2007

Pediatric IBDInfliximab
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Sicurezza dell’Infliximab in bambini con malattia infiammatoria cronica intestinale (IBD): Registro pediatrico italiano di terapia biologica per le I…

2008

MICI PediatricheInfliximab
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IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

2018

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 ca…

AdultMaleMultifactorial InheritanceQUANTITATIVE TRAIT LOCUSGenotypeSEQUENCING DATAQuantitative Trait LociSUSCEPTIBILITYPolymorphism Single NucleotideArticleCohort StudiesCODING VARIANTSCrohn Disease80 and overJournal ArticleMedicine and Health SciencesLOCUSHumansGenetic Predisposition to DiseasePolymorphismGENOME-WIDE ASSOCIATIONGenetic Association StudiesAgedAged 80 and overScience & TechnologyAdult; Aged; Aged 80 and over; Cohort Studies; Crohn Disease; Female; Gene Expression Profiling; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Polymorphism Single Nucleotide; Quantitative Trait Loci; Sequence Analysis DNA; Multifactorial InheritanceGene Expression ProfilingCOMPLEX TRAITSBiology and Life SciencesSequence Analysis DNASingle NucleotideDNAMiddle AgedInflammatory Bowel DiseasesCROHNS-DISEASEMultidisciplinary SciencesQUANTITATIVE TRAITRARE VARIANTSScience & Technology - Other TopicsFemaleLOW-FREQUENCYSequence AnalysisINFLAMMATORY-BOWEL-DISEASE
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