0000000000935102

AUTHOR

Kathrin Sundberg

showing 2 related works from this author

Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.

1998

AbstractEpidemiological studies suggest that individuals differing in the expression of allelic variants of the human glutathione transferase (GST) Pi gene differ in susceptibility to chemical carcinogens such as polycyclic aromatic hydrocarbons (PAH). This study reports the catalytic efficiencies (kcat/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site. The results indicate that individuals who are homozygous for the allele encoding GSTP1-1/V-105 might be more susceptible to PAH carcinogenesis due to…

StereochemistryCarcinogenesisMutantBiophysicsPolycyclic aromatic hydrocarbonurologic and male genital diseasesBiochemistryCatalysischemistry.chemical_compoundStructure-Activity RelationshipStructural BiologyGeneticspolycyclic compoundsStructure–activity relationshipHumansGlutathione conjugationPolycyclic Aromatic HydrocarbonsMolecular BiologyGeneneoplasmsCarcinogenGlutathione Transferasechemistry.chemical_classificationbiologyMolecular StructureChemistryActive siteGenetic VariationBiological activityCell BiologyGlutathioneGlutathioneFjord regionPolycyclic aromatic hydrocarbonKineticsBiochemistryDiol epoxideHuman glutathione transferase P1-1Inactivation Metabolicbiology.proteinCarcinogensFEBS letters
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Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

1997

Metabolism of polycyclic aromatic hydrocarbons in mammalian cells results in the formation of vicinal diol epoxides considered as ultimate carcinogens if the oxirane ring is located in a bay- or fjord-region of the parent compound. In the present study, individual stereoisomers of the bay-region diol epoxides of chrysene, dibenz[a,h]anthracene, and benzo[a]pyrene as well as of the fjord-region diol epoxides of benzo[c]phenanthrene, benzo[c]chrysene, and benzo[g]-chrysene have been incubated with GSH in the presence of human glutathione transferases GSTM1-1 (a mu-class enzyme) and GSTP1-1 (a pi-class enzyme). As previously shown with GSTA1-1 (an alpha-class enzyme) both M1-1 and P1-1 demonst…

Models MolecularChryseneStereochemistryConjugated systemToxicologySubstrate Specificitychemistry.chemical_compoundpolycyclic compoundsHumansPolycyclic Aromatic HydrocarbonsCarcinogenGlutathione TransferaseBay-Region Polycyclic Aromatic Hydrocarbonchemistry.chemical_classificationAnthraceneintegumentary systemStereoisomerismGeneral MedicineGlutathionePhenanthreneGlutathioneIsoenzymesKineticsEnzymechemistryCarcinogensEpoxy CompoundsPyreneCrystallizationChemical Research in Toxicology
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