0000000000937120

AUTHOR

Davide Piffer

showing 2 related works from this author

Holocene selection for variants associated with cognitive ability: Comparing ancient and modern genomes

2017

ABSTRACTHuman populations living in Eurasia during the Holocene experienced considerable microevolutionary change. It has been predicted that the transition of Holocene populations into agrarianism and urbanization brought about culture-gene coevolution that favoured via directional selection genetic variants associated with higher general cognitive ability (GCA). To examine whether GCA might have risen during the Holocene, we compare a sample of 99 ancient Eurasian genomes (ranging from 4.56 to 1.21 kyr BP) with a sample of 503 modern European genomes, using three different cognitive polygenic scores. Significant differences favouring the modern genomes were found for all three polygenic s…

Geneticseducation.field_of_studyDirectional selectionEvolutionary biologyPopulationGenomicsOdds ratioBiologyAlleleeducationGenomeSelection (genetic algorithm)Holocene
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Holocene Selection for Variants Associated With General Cognitive Ability: Comparing Ancient and Modern Genomes

2017

Human populations living during the Holocene underwent considerable microevolutionary change. It has been theorized that the transition of Holocene populations into agrarianism and urbanization brought about culture-gene co-evolution that favored via directional selection genetic variants associated with higher general cognitive ability (GCA). To examine whether GCA might have risen during the Holocene, we compare a sample of 99 ancient Eurasian genomes (ranging from 4.56 to 1.21 kyr BP) with a sample of 503 modern European genomes (Fst= 0.013), using three different cognitive polygenic scores (130 SNP, 9 SNP and 11 SNP). Significant differences favoring the modern genomes were found for al…

0301 basic medicineMaleMultifactorial InheritanceSingle-nucleotide polymorphismBiologyGenomePolymorphism Single NucleotideEvolution Molecular03 medical and health sciences0302 clinical medicineCognitionSNPHumansAlleleSelection GeneticGenetics (clinical)Selection (genetic algorithm)HoloceneModels GeneticDirectional selectionGenome HumanObstetrics and GynecologyOdds ratio030104 developmental biologyEvolutionary biologyPediatrics Perinatology and Child HealthFemale030217 neurology & neurosurgery
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