0000000000937333
AUTHOR
H. Hein
Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea : data from the European Sleep Apnea Database (ESADA)
Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP …
Prototype of an angular-selective photoelectron calibration source for the KATRIN experiment
The method of direct neutrino mass determination based on the kinematics of tritium beta decay, which is adopted by the KATRIN experiment, makes use of a large, high-resolution electrostatic spectrometer with magnetic adiabatic collimation. In order to target a sensitivity on the neutrino mass of 0.2 eV/c^2, a detailed understanding of the electromagnetic properties of the electron spectrometer is essential, requiring comprehensive calibration measurements with dedicated electron sources. In this paper we report on a prototype of a photoelectron source providing a narrow energy spread and angular selectivity. Both are key properties for the characterisation of the spectrometer. The angular …
Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort
The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analyse…
An angular-selective electron source for the KATRIN experiment
The KATRIN experiment is going to search for the average mass of the electron antineutrino with a sensitivity of 0.2 eV/c2. It uses a retardation spectrometer of MAC-E filter type to accurately measure the shape of the electron spectrum at the endpoint of tritium beta decay. In order to achieve the planned sensitivity the transmission properties of the spectrometer have to be understood with high precision for all initial conditions. For this purpose an electron source has been developed that emits single electrons at adjustable total energy and adjustable emission angle. The emission is pointlike and can be moved across the full flux tube that is imaged onto the detector. Here, we demonstr…
Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)
Abstract.Gunduz C, Basoglu OK, Hedner J, et al; onbehalf of the European Sleep Apnoea Databasecollaborators (Biruni University; Ege University;Gothenburg University; Sahlgrenska UniversityHospital; University of Palermo; CNR Institute ofBiomedicine and Molecular Immunology; St. AdolfStift; Hospital de Santa Maria; University of Crete;Antoine-Beclere Hospital; G. PapanikolaouHospital; Institute of Tuberculosis and LungDiseases; University Hospital Brno; St. Ann’sUniversity Hospital; Universite ́ Grenoble Alpes)Hyperlipidaemia prevalence and cholesterolcontrol in obstructive sleep apnoea: Data from theEuropean sleep apnea database (ESADA).J InternMed2019;286: 676–688.Background and objective.…
Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study
[No abstract available]
Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database
Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profil…