Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Methods A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici D…

RECUPERO ENERGETICO DELLE BIOMASSE IN VITIVINICOLTURA : IL CASO SETTESOLI

Recupero energetico delle biomasse in vitivinicoltura: valutazione di un caso aziendale

GERMLINE PROKINETICIN RECEPTOR 2 (PROKR2) VARIANTS ASSOCIATED WITH CENTRAL HYPOGONADISM CAUSE DIFFERENTAL MODULATION OF DISTINCT INTRACELLULAR PATHWAYS.

INTRODUCTION: Defects of prokineticin pathway affect the neuroendocrine control of reproduction, but their role in the pathogenesis of central hypogonadism remains undefined, and the functional impact of the missense PROKR2 variants has been incompletely characterized. MATERIAL AND METHODS: In a series of 246 idiopathic central hypogonadism patients, we found three novel (p.V158I, p.V334M, and p.N15TfsX30) and six already known (p.L173R, p.T260M, p.R268C, p.V274D, p.V331M, and p.H20MfsX23) germline variants in the PROKR2 gene. We evaluated the effects of seven missense alterations on two different prokineticin receptor 2 (PROKR2)-dependent pathways: inositol phosphate-Ca(2+) (Gq coupling) a…

L’allevamento bovino nella valle del Torto: un caso di zootecnia sostenibile in Sicilia

In spite of not being the main activities of Sicilian agriculture, zootechny plays a very important social role, even more than economic, for a large part of Sicily. The crisis that has hit the industry since early 2000s, and particularly cattle livestock, caused the closure of many holdings and a strong decrease in the number of animals bred, both meat and dairy cattle. The beef cattle population in the Valle del Torto, in the province of Palermo (area covered by this study), for many decades has significantly contributed to the development of a rural community that trough this activity created his own wealth, income and economic stability. The crisis that over the last decade has affected…

Agricultural quality products for territorial evaluation and tourism development in Sicily: the Pantelleria case

The Agri-Food system is determined and conditioned by the effects of great phenomena, strictly related to territorial, environmental, social, political and economical aspects. Thus, agriculture has to carry out complex roles within the multi-functionality framework throughout production of healthy products, safeguard and protection of environment and territory, preservation and safeguard of bio-diversity, and by supplying goods and services to public, integrating with industry and agrifood distribution. Within such scenery, developed Countries, and in particular those of the EU, carry out strategies in order to adjust to new agrifood market conditions, and to respond to citizens-consumers i…