0000000000947565
AUTHOR
Vincenza Compagno
Regulation of the expression of RNA-binding proteins in developing and adult rat brains: the role of thyroid hormones
Toxic adenoma and papillary thyroid carcinoma in a patient with Graves' disease.
A case of a very rare association of toxic adenoma and papillary carcinoma with Graves’ disease is presented. A 34-year-old woman developed Graves’ disease with mild ophthalmopathy. An ultrasound revealed diffuse thyroid enlargement with a hypoechoic pattern and a hypoechoic nodule with regular edges of 1.6 cm in diameter at the lower pole of the left lobe. A thyroid 131I scintiscan showed a diffuse and homogeneous 131I distribution. The 131I uptake (RAIU) was elevated. One year later, while still on a low dose of methimazole, the patient had a recurrence of hyperthyroidism following an iodine load from a contrast agent. A further thyroid ultrasound confirmed the previously described patter…
La determinazione degli anticorpi anti-peptide ciclico citrullinato è utile nel discriminare pazienti con artrite reumatoide da quelli con poliartrite associata a tiroidite cronica autoimmune
EFFECTS OF THYROID HORMONES ON TWO PUTATIVE RNA-BINDING PROTEINS EXPRESSED IN DEVELOPING RAT BRAIN.
Effects of thyroid hormones on RNA-binding proteins involved in the regulation of H1° and H3.3 histone variant expression
EFFECTS OF THYROID HORMONES ON RNA-BINDING PROTEINS EXPRESSED IN DEVELOPING RAT BRAIN
Effects of thyroid hormones on sumoylation of the RNA-binding protein PIPPin
EFFETTO DEGLI ORMONI TIROIDEI SULL’ESPRESSIONE DELLE PROTEINE PIPPIN ED LPI NEL CERVELLO DI RATTO IN SVILUPPO.
Circulating endothelin-1 levels in type 2 diabetic patients with ischaemic heart disease.
To investigate whether circulating endothelin-1 (Et-1) may be related to the increased incidence and severity of ischaemic heart disease in type 2 diabetes mellitus, we compared the concentrations in type 2 diabetic patients and in non-diabetic patients with coronary artery disease (CAD) angiographically documented. Plasma levels of Et-1 were determined in 34 type 2 diabetic patients with CAD (16 with stable angina, 6 with unstable angina, 12 with previous myocardial infarction) and in 19 nondiabetic patients with CAD (4 with stable angina, 5 with unstable angina, 10 with previous myocardial infarction). Fifteen diabetic patients without CAD and 9 healthy volunteers served as control subjec…
Effects of thyroid hormones on RNA-binding proteins involved the regulation on H1° and H3,3 histone variant expression.
Effects of thyroid hormones on the expression of two rat brain proteins: PIPPin and the long PEP-19 isoform (LPI)
POST-TRANSCRIPTIONAL REGULATION BY THYROID HORMONES OF SOME BRAIN-SPECIFIC PROTEINS PROBABLY INVOLVED IN RNA METABOLISM.
Cardiac changes in subclinical and overt hyperthyroid women: retrospective study
This retrospective and descriptive 4-year study was undertaken to describe cardiac changes in subclinical and overt hyperthyroidism.We revised the charts of 386 consecutive cardiopathic women whose blood samples were referred to the Radioimmunoassay Laboratory to evaluate thyroid function from 1 January 1997 through 31 December 2000.After excluding women because euthyroid or hypothyroid, or taking amiodarone and women with hypertension, rheumatic disease, myocardial infarction, a total of 31 hyperthyroid women were thus selected for the study: 19 with subclinical hyperthyroidism and 12 with overt hyperthyroidism. The prevalence of atrial fibrillation did not differ between subclinical (48%)…
ROLE OF THYROID HORMONES IN DEVELOPING RAT BRAIN AND IN CULTURED NEURONS
Thyroid hormones induce sumoylation of the cold shock domain-containing protein PIPPin in developing rat brain and in cultured neurons.
We previously identified a cold shock domain (CSD)-containing protein (PIPPin), expressed at high level in brain cells. PIPPin has the potential to undergo different post-translational modifications and might be a good candidate to regulate the synthesis of specific proteins in response to extracellular stimuli. Here we report the effects of thyroid hormone (T3) on PIPPin expression in developing rat brain. We found that a significant difference among euthyroid- and hypothyroid- newborn rats concerns sumoylation of nuclear PIPPin, that is abolished by hypothyroidism. Moreover, T3-dependence of PIPPin sumoylation has been confirmed in cortical neurons purified from brain cortices and culture…
Effect of aging and hypertension on β-myosin heavy chain in heart of spontaneously hypertensive rats
During aging rat myocardium undergoes structural changes characterized by a shift in the synthesis of myosin heavy chain (MHC) from V1 isoform, composed of two alpha-MHC, to V3 isoform, composed of two beta-MHC. In rat, besides ageing, cardiac hypertrophy as adaptive response to a superimposed pressure load (such as hypertension) is characterized by predominance of V3 myosin isoform. The aim of our study was to evaluate the expression of beta-MHC in right (RV) and left (LV) ventricles of spontaneously hypertensive rats (SHRs), a well defined animal model of hypertension, in relation to aging. We used very young (8-week old) and young (15-week old) SHRs and age-matched normotensive Harlan Sp…