0000000000950957
AUTHOR
Luis Marco
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium
Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen …
Lyapunov Functions for Second-Order Differential Inclusions: A Viability Approach
AbstractIn this paper the existence of Lyapunov functions for second-order differential inclusions is analyzed by using the methodology of the Viability Theory. A necessary assumption on the initial states and sufficient conditions for the existence of local and global Lyapunov functions are obtained. An application is also provided.