0000000000951244

AUTHOR

Lidia Hirnle

0000-0001-9789-5370

showing 1 related works from this author

Metabolomics of Human Amniotic Fluid and Maternal Plasma during Normal Pregnancy

2016

Metabolic profiles of amniotic fluid and maternal blood are sources of valuable information about fetus development and can be potentially useful in diagnosis of pregnancy disorders. In this study, we applied 1H NMR-based metabolic profiling to track metabolic changes occurring in amniotic fluid (AF) and plasma (PL) of healthy mothers over the course of pregnancy. AF and PL samples were collected in the 2nd (T2) and 3rd (T3) trimester, prolonged pregnancy (PP) until time of delivery (TD). A multivariate data analysis of both biofluids reviled a metabolic switch-like transition between 2nd and 3rd trimester, which was followed by metabolic stabilization throughout the rest of pregnancy proba…

B Vitamins0301 basic medicineAmniotic fluidPhysiologyMaternal HealthPlacentalcsh:MedicineSpectrum analysis techniquesBiochemistryAcetoacetatesFetal DevelopmentPlasmachemistry.chemical_compoundGlucose MetabolismPregnancyPyruvic AcidBlood plasmaMedicine and Health SciencesMetabolitesAmino Acidslcsh:ScienceMultidisciplinary3-Hydroxybutyric AcidOrganic CompoundsObstetrics and GynecologyHematologyVitaminsKetonesBody FluidsChemistryBloodmedicine.anatomical_structurePregnancy Trimester SecondPhysical SciencesMetabolomeKetone bodiesCarbohydrate MetabolismFemaleAnatomyResearch Articlemedicine.drugPyruvateAdultmedicine.medical_specialtyPregnancy Trimester ThirdGestational AgeCholinesBiologyBlood PlasmaYoung Adult03 medical and health sciencesNMR spectroscopyInternal medicinePlacentamedicineHumansMetabolomicsCarnitineFetusPregnancy030102 biochemistry & molecular biologylcsh:ROrganic ChemistryChemical CompoundsBiology and Life SciencesAmniotic Fluidmedicine.diseaseResearch and analysis methodsMetabolismGlucose030104 developmental biologyEndocrinologychemistryWomen's Healthlcsh:QPyruvic acidAcidsPLOS ONE
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