0000000000951514

AUTHOR

Maja Mitrović

showing 1 related works from this author

The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response

2012

ABSTRACT Natural killer (NK) cells and CD8 + T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8 + T-cell response to MCMV infection is still the subject of intensive research. For analyzing the impact of NK cells on mounting of a CD8 + T-cell response and the contribution of these cells to virus control during the first days postinfection (p.i.), we used C57BL/6 mice in which NK cells are specifically activated through the Ly49H receptor engaged by the MCMV-encoded ligand m157. Our results indicate that the requirement for CD8 + T cells in early MCMV control inversely correlates with the engagement of Ly49H. W…

MaleMuromegalovirusImmunologyNK cellsCD8-Positive T-LymphocytesBiologym157MicrobiologyRodent DiseasesMice03 medical and health sciencesInterleukin 210302 clinical medicineVirologyAnimalsCytotoxic T cellmouse cytomegalovirus; NK cells; T-cell response; Ly49H; m157IL-2 receptor030304 developmental biologyMice Inbred BALB C0303 health sciencesJanus kinase 3ZAP70BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences.Herpesviridae InfectionsNatural killer T cellMouse cytomegalovirus3. Good healthKiller Cells NaturalMice Inbred C57BLKineticsT-cell responseInsect ScienceImmunologyInterleukin 12CytokinesPathogenesis and ImmunityFemaleLy49HBIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti.CD8030215 immunology
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