0000000000958533

AUTHOR

K. Picard

showing 4 related works from this author

Estrogenic activity and metabolism of N-butyl benzyl phtalate in vitro : identification of the active molecule(s)

2001

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]activité oestrogeno-mimétiqueComputingMilieux_MISCELLANEOUS
researchProduct

Metabolism of n-Butyl Benzyl Phthalate in the Female Wistar Rat. Identification of New Metabolites

1999

International audience; n-Butyl benzyl phthalate (BBP), a plasticizer used in polyvinylchloride (PVC) and other polymers, has been orally administered to female Wistar rats with four doses (150, 475, 780 and 1500 mg/kg body weight/day) for 3 consecutive days. Metabolites recovered in urines were analysed by gas chromatography±mass spectrometry (GC±MS) after 24, 48 and 72 hours. Six metabolites were identi®ed. Mono-n-butyl phthalate (MBuP) and mono-n-benzyl phthalate (MBeP) represented respectively 29± 34% and 7±12 % of the total recovered metabolites. Hippuric acid, the main metabolite of benzoic acid, represented the second major metabolite (51±56%). Phthalic acid, benzoic acid and an o-ox…

MetabolitePhthalic Acids[SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chainUrine010501 environmental sciencesToxicology01 natural sciencesGas Chromatography-Mass Spectrometry03 medical and health scienceschemistry.chemical_compoundPharmacokineticsPlasticizersFemale rat.MetabolitesAnimalsToxicokineticsn-butyl benzyl phthalateRats Wistar030304 developmental biology0105 earth and related environmental sciencesBenzoic acid0303 health sciencesChromatographyMolecular StructureHippuratesPhthalateHippuric acidGeneral MedicineRats3. Good healthPhthalic acidTeratogensMetabolismDiazomethane[SDV.TOX.TCA] Life Sciences [q-bio]/Toxicology/Toxicology and food chainchemistryFemaleOxidation-ReductionFood ScienceFood and Chemical Toxicology
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Metabolism of N-butyl benzyl phtalate in the female wistar rat. Identification of new metabolites

1999

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]RATComputingMilieux_MISCELLANEOUS
researchProduct

Oligandrin. A proteinaceous molecule produced by the mycoparasite Pythium Oligandrum induces resistance to Phytophthora parasitica infection in tomat…

2000

International audience

OLIGANDRINE[SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics[SDV.GEN.GPL] Life Sciences [q-bio]/Genetics/Plants geneticsComputingMilieux_MISCELLANEOUS
researchProduct