0000000000961127

AUTHOR

Kt Khaw

showing 3 related works from this author

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representat…

2021

Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prev…

MaleLatin AmericansNutrition and DiseaseEpidemiology[SDV]Life Sciences [q-bio]MedizinBLOOD-PRESSURE030204 cardiovascular system & hematologyWorldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.Hypertension ; Prevalence ; Control ; TretamentGUIDELINESGlobal HealthWorldwide trends0302 clinical medicineHypertension prevalenceVoeding en ZiekteMedicine and Health Scienceskohonnut verenpainePrevalenceMedicine030212 general & internal medicinePrevention and Control11 Medical and Health SciencesComputingMilieux_MISCELLANEOUSHypertension prevalenceeducation.field_of_studyfood and beveragesPublic Health Global Health Social Medicine and EpidemiologyGeneral MedicineNoncommunicable diseases; Hypertension; Period prevalenceMiddle Agedkansainvälinen vertailu3142 Public health care science environmental and occupational health3. Good healthMIDDLE-INCOMEPooled analysisBLOOD-PRESSURE; SYSTEMATIC ANALYSIS; INCOME COUNTRIES; MIDDLE-INCOME;ADULTS;PREVENTION;GUIDELINES;MANAGEMENT;ADHERENCE;DIAGNOSISWestern europeHypertension[SDE]Environmental SciencesHypertension/diagnosisNCD Risk Factor Collaboration (NCD-RisC)FemaleB990 Subjects Allied to Medicine not elsewhere classifiedLife Sciences & BiomedicineAdulthealth-careesiintyvyysCentral asiaPopulationNursing.3121 Internal medicineDIAGNOSIS03 medical and health sciencesMedicine General & InternalADHERENCEDrug TherapyGeneral & Internal MedicineControlMANAGEMENTSYSTEMATIC ANALYSISLife ScienceHumansddc:610INCOME COUNTRIESeducationAntihypertensive AgentsVLAGAgedScience & TechnologyAntihypertensive Agents/therapeutic usebusiness.industryOmvårdnadfungiGeneral and internal medicineADULTSEstados de Saúde e de DoençaPREVENTIONTaking medicationTreatmentFolkhälsovetenskap global hälsa socialmedicin och epidemiologiBlood pressureFaculdade de Ciências Sociais3121 General medicine internal medicine and other clinical medicinelääkehoito1182 Biochemistry cell and molecular biologybusinessDemography
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

2011

1. The CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 2011;43:333–338. ### Study Hypothesis Recently, genome-wide association studies (GWAS) have identified several common variants that are associated with risk of coronary artery disease (CAD) and myocardial infarction (MI). The authors state that the current loci discovered in CAD and MI GWAS explain only a small fraction of the heritability of this complex disease. The authors hypothesized that a larger study would provide more power to discover common variants with modest effect sizes. Therefore, they formed the Coronary ARtery DIsease Genome-wid…

AdultMaleMultifunction cardiogramLocus (genetics)Single-nucleotide polymorphismGenome-wide association studyCoronary Artery DiseaseBiologyPolymorphism Single NucleotideGenetic determinismartery diseaseArticleCoronary artery diseaseGene FrequencySDG 3 - Good Health and Well-beingRisk FactorsGeneticsmedicineHumansGenetic Predisposition to Diseasecardiovascular diseasesAlleleGenotypingAllele frequencycoronaryAllelesGenetics (clinical)AgedGenetic associationGeneticsbusiness.industrycoronary; artery diseaseCase-control studyMiddle Agedmedicine.diseasecoronary artery disease; Large-scale association analysisCase-Control StudiesFemaleCardiology and Cardiovascular MedicinebusinessGenome-Wide Association Study
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Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

2011

Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through w…

MaleCancer ResearchCandidate geneEpidemiologyGenome-wide association studyCoronary Artery Disease030204 cardiovascular system & hematologyCardiovascular0302 clinical medicineGENETICS & HEREDITYGenetics (clinical)Genetics0303 health sciencesCardiovascular diseases [NCEBP 14]Middle Aged3. Good healthCYP17A1Genetic EpidemiologyGenome-wide association; Myocardial-infarction; Susceptibility loci; Risk; Atherosclerosis; Metanalysis; LipoproteinMedicineFemaleLife Sciences & BiomedicineResearch ArticleAsian Continental Ancestry GroupAdultRiskSUSCEPTIBILITY LOCIlcsh:QH426-470European Continental Ancestry GroupBiologyPolymorphism Single Nucleotidecoronary artery disease; geneticsWhite People03 medical and health sciencesSDG 3 - Good Health and Well-beingAsian PeopleGenetic variationGeneticsHumansGenetic Predisposition to DiseaseGENOME-WIDE ASSOCIATIONAlleleMolecular BiologyGeneBiologyMETAANALYSISEcology Evolution Behavior and SystematicsGenetic Association StudiesCardiovascular Disease EpidemiologyAlleles030304 developmental biologyAged0604 GeneticsScience & TechnologyCase-control studyGenetic VariationHuman GeneticsOdds ratiolarge-scale gene analysiscoronary artery disease; large-scale gene analysislcsh:GeneticsLIPOPROTEINMYOCARDIAL-INFARCTIONATHEROSCLEROSISCase-Control StudiesGenetics of DiseaseIBC 50K CAD ConsortiumDevelopmental BiologyGenome-Wide Association Study
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