Additional file 2: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (PDF 122 kb).

Erratum: Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): Study protocol for a randomized controlled trial [Trials, 18, (2017)(202)] DOI: 10.1186/s13063-017-1929-0

Additional file 1: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

PROBESE Study protocol version 2.5. This PDF file includes the most recent version of the PROBESE Study protocol with changes highlighted. (PDF 870Â kb)

The stellar content of the XMM-Newton Bright Serendipitous Survey

Context: The comparison of observed counts in a given sky direction with predictions by Galactic models yields constraints to the spatial distribution and the stellar birthrate of young stellar populations. In this work we present the results of the analysis of the stellar content of the XMM-Newton Bright Serendipitous Survey (XBSS). This unbiased survey includes a total of 58 stellar sources selected in the 0.5 -- 4.5 keV energy band, having a limiting sensitivity of $10^{-2}$ cnt s$^{-1}$ and covering an area of 28.10 sq. deg. Aims: Our main goal is to understand the recent star formation history of the Galaxy in the vicinity of the Sun. Methods: We compare the observations with the predi…

Additional file 1: of Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial

PROTHOR-Patient information. (DOCX 19 kb)

The NHXM observatory

Exploration of the X-ray sky has established X-ray astronomy as a fundamental astrophysical discipline. While our knowledge of the sky below 10 keV has increased dramatically (∼8 orders of magnitude) by use of grazing incidence optics, we still await a similar improvement above 10 keV, where to date only collimated instruments have been used. Also ripe for exploration is the field of X-ray polarimetry, an unused fundamental tool to understand the physics and morphology of X-ray sources. Here we present a novel mission, the New Hard X-ray Mission (NHXM) that brings together for the first time simultaneous high-sensitivity, hard-X-ray imaging, broadband spectroscopy and polarimetry. NHXM will…

Additional file 4: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Standard operating procedures (SOP) for plasma Sampling. (PDF 115Â kb)

Additional file 1: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

PROBESE Study protocol version 2.5. This PDF file includes the most recent version of the PROBESE Study protocol with changes highlighted. (PDF 870Â kb)

XIPE: the x-ray imaging polarimetry explorer

XIPE, the X-ray Imaging Polarimetry Explorer, is a mission dedicated to X-ray Astronomy. At the time of writing XIPE is in a competitive phase A as fourth medium size mission of ESA (M4). It promises to reopen the polarimetry window in high energy Astrophysics after more than 4 decades thanks to a detector that efficiently exploits the photoelectric effect and to X-ray optics with large effective area. XIPE uniqueness is time-spectrally-spatially- resolved X-ray polarimetry as a breakthrough in high energy astrophysics and fundamental physics. Indeed the payload consists of three Gas Pixel Detectors at the focus of three X-ray optics with a total effective area larger than one XMM mirror bu…

Additional file 3: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

PROBESE case report form version 1.2.2. This file corresponds to the paper version of the case report form. (DOC 1610 kb).

The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

Abstract Background It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries.…

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Background Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multice…

Additional file 2: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (PDF 122 kb).

Additional file 5: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Standard operating procedures (SOP) for plasma Sampling. (PDF 110Â kb)

Additional file 3: of Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

PROBESE case report form version 1.2.2. This file corresponds to the paper version of the case report form. (DOC 1610 kb).

Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.

Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM.PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two different intraoperative me…