0000000000963201
AUTHOR
Simone Filosto
showing 19 related works from this author
Cadmium induces an apoptotic response in sea urchin embryos.
2007
Cadmium is a heavy metal toxic for living organisms even at low concentrations. It does not have any biological role, and since it is a permanent metal ion, it is accumulated by many organisms. In the present paper we have studied the apoptotic effects of continuous exposure to subacute/sublethal cadmium concentrations on a model system: Paracentrotus lividus embryos. We demonstrated, by atomic absorption spectrometry, that the intracellular amount of metal increased during exposure time. We found, using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay, that long treatments with cadmium triggered a severe DNA fragmentation. We demonstrated, by immunocytochemistry …
Cadmium accumulation induces apoptosis in sea urchin embryos and larvae
2006
Cadmium effects on sea urchin embryos
2005
Apoptotic pathway induced by cadmium in sea urchin embryos
2005
Cadmium insult and defence mechanisms in Paracentrotus lividus embryos and larvae.
2007
Cadmium accumulation induces apoptosis in P. lividus larvae.
2007
Apoptosis during early development of sea urchin.
2008
Apoptosis is a genetic program of cell death that eliminates superfluous or compromised cells during development and adult life of many organisms. In sea urchin embryos, apoptosis is not only a physiological event during larval metamorphosis, but also a process induced by cadmium accumulation or other stressor like TPA (12-O-tetradecanoylphorbol-13-acetate) followed by an increase of temperature to 31°C. Apoptosis is a highly conserved process usually operated by a proteolytic cascade that involves caspase activation by two different pathways: extrinsic and intrinsic. The first one involves membrane death receptors, while the second involves mitochondria. In this work we analyzed the possib…