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Human settlements in the Mediterranean and the sea level changes from 12 ka to the present
2012
Understanding past sea-level change plays an important role in determining the underlying causes, and also allows the extrapolation of past sea levels to locations and epochs for which there are no instrumental data. A compilation of global sea-level estimates based on deep-sea oxygen isotope ratios at millennial-scale resolution or higher was published since ‘70. These global sea level curves do not take in account isostasy and tectonics. Observed sea level change can be reconstructed from dated fossils, coral reef terraces, speleothems, emerged and forming terraces on coastal areas, archaeological and other markers well connected with sea level. Because of the lack of coral reefs in the M…
Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
2019
Background Genomic instability is a feature of multiple myeloma (MM), and impairment in DNA damaging response (DDR) has an established role in disease pathobiology. Indeed, a deregulation of DNA repair pathways may contribute to genomic instability, to the establishment of drug resistance to genotoxic agents, and to the escape from immune surveillance. On these bases, we evaluated the role of different DDR pathways in MM and investigated, for the first time, the direct and immune-mediated anti-MM activity of the nucleotide excision repair (NER)-dependent agent trabectedin. Methods Gene-expression profiling (GEP) was carried out with HTA2.0 Affymetrix array. Evaluation of apoptosis, cell cyc…