0000000000965579

AUTHOR

Adelina Gonzalez

showing 3 related works from this author

Renin-angiotensin system inhibitors effect before and during hospitalization in COVID-19 outcomes: Final analysis of the international HOPE COVID-19 …

2021

Background The use of Renin-Angiotensin system inhibitors (RASi) in patients with coronavirus disease 2019 (COVID-19) has been questioned because both share a target receptor site. Methods HOPE-COVID-19 (NCT04334291) is an international investigator-initiated registry. Patients are eligible when discharged after an in-hospital stay with COVID-19, dead or alive. Here, we analyze the impact of previous and continued in-hospital treatment with RASi in all-cause mortality and the development of in-stay complications. Results We included 6503 patients, over 18 years, from Spain and Italy with data on their RASi status. Of those, 36.8% were receiving any RASi before admission. RASi patients were …

QA75Malemedicine.medical_specialtyHeart diseaseInfecciones por coronavirusmedicine.medical_treatmentInhibidores enzimáticosPopulationClinical InvestigationsEnfermedad transmisibleAngiotensin-Converting Enzyme InhibitorsSistema renina-angiotensinaComorbidity030204 cardiovascular system & hematologySeverity of Illness Index03 medical and health sciences0302 clinical medicineRisk FactorsOutcome Assessment Health CareSeverity of illnessmedicineHumansRegistries030212 general & internal medicineMedical prescriptioneducationHeart FailureMechanical ventilationeducation.field_of_studySARS-CoV-2business.industryCOVID-19Middle AgedPrognosismedicine.diseaseR1Respiration ArtificialComorbidityHospitalizationItalySpainHeart failureEmergency medicineFemaleObservational studyCardiology and Cardiovascular MedicinebusinessAmerican Heart Journal
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Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19.

2020

Abstract Background the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients. Methods post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65–74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality. Results about, 1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71–83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), card…

MaleAgingmedicine.medical_specialtyInternational CooperationPopulation030204 cardiovascular system & hematologycomorbiditiesRisk Assessment03 medical and health sciencesAcademicSubjects/MED002800302 clinical medicineRisk FactorsInternal medicineEpidemiologymedicineClinical endpointDementiaHumans030212 general & internal medicineHospital MortalityRegistriesMortalityeducationGeriatric Assessmentolder adultsAgedAged 80 and overeducation.field_of_studyCoronavirus disease 2019business.industrySARS-CoV-2COVID-19MultimorbidityGeneral Medicinemedicine.diseasePrognosisComorbidityHospitalizationAgeingIntensive Care UnitsRespiratory failureHeart failureFemaleGeriatrics and GerontologybusinessDyslipidemiaResearch PaperAge and ageing
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Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID-19

2021

Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular risk factors and more comorbidities at baseline. After propensity score matching, 876 men and 876 women were selected. Male patients more often reported fever, whereas female patients more often reported vomiting, diarrhea, and hyposmia/anosmia. Laboratory tests in men presented alterations consistent w…

Malemedicine.medical_specialtyLeadership and ManagementAnosmiaComorbidityAssessment and DiagnosisCohort Studies03 medical and health sciencesSex Factors0302 clinical medicineHyposmiaInternal medicinemedicineHumans030212 general & internal medicine030223 otorhinolaryngologyCare PlanningAgedAged 80 and overbusiness.industryHealth PolicyCOVID-19General MedicineMiddle Agedmedicine.diseaseComorbidityHospitalizationSystemic inflammatory response syndromeHeart Disease Risk FactorsPropensity score matchingDisease ProgressionVomitingFemaleFundamentals and skillsmedicine.symptomLymphocytopeniabusinessCohort studyJournal of Hospital Medicine
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