Author: Melita Magone

0000000000976935

AUTHOR

Melita Magone

showing 1 related works from this author

Expression of the Sonic Hedgehog Embryonic Signalling Pathway Components in Matched Pre-Treatment and Relapsed Small Cell Lung Cancer Biopsies

2021

Abstract Cancer stem cells may be responsible for tumour regrowth and acquisition of resistance in small cell lung cancer (SCLC). The Hedgehog pathway regulates survival and proliferation of tissue progenitor and stem cell populations, promoting the expression of stem cell related and proliferative genes. We evaluated the Sonic Hedgehog (Shh) embryonic signalling pathway in relapsed SCLC. Expression levels of Shh related genes GLI1, SMO, SUFU, PTCH1, HHIP, BCL2, BMI, ZEB1, ZEB2, N-MYC, Twist1 were analysed by qRT-PCR in matched pre-treatment and relapsed tumour fresh frozen biopsies of three SCLC patients. Expression of each gene was compared using the paired samples t-test, as well as comp…

Pre treatmentbiologybiology.proteinCancer researchSonic hedgehogEmbryonic stem cellRelapsed Small Cell Lung CancerHedgehog signaling pathwayProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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